Structure, function, and defect tolerance with maturation of the radial tie fiber network in the knee meniscus.
Structure, function, and defect tolerance with maturation of the radial tie fiber network in the knee meniscus.
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DOI：
10.1002/jor.24697
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Zgonis MH
中科院分区：
文献类型：
--
作者：
Bansal S;Peloquin JM;Keah NM;O'Reilly OC;Elliott DM;Mauck RL;Zgonis MH
膝关节半月板由两个相互垂直的胶原网络组成——环形网络和放射状网络，这两个网络相结合使成年人的半月板组织能够有效地承受负荷。在此，我们评估了这些网络的结构和功能特性在骨骼成熟过程中是如何发展的，并确定了这些纤维网络在组织损伤时对缺陷耐受性的作用。对来自胎儿、幼年和成年牛内侧半月板的放射状连接纤维（RTF）胶原结构进行成像显示，随着骨骼发育，其异质性、各向异性、厚度和密度都在增加。力学分析表明，尽管与胎儿组织相比，成年组织在径向的回弹性增加，在环形方向对缺陷的耐受性降低，但径向的拉伸模量并不随骨骼发育而改变。这种缺陷耐受性的丧失与成年组织中RTF网络的有序性增加相关。这些数据为放射状纤维网络在半月板功能中的作用提供了新的见解，将有助于在半月板撕裂时改进临床决策，并可能改进在膝关节中重现这一关键承重结构的工程努力。
The knee menisci are comprised of two orthogonal collagenous networks – circumferential and radial – that combine to enable efficient load bearing by the tissue in adults. Here, we assessed how the structural and functional characteristics of these networks developed over the course of skeletal maturation and determined the role of these fiber networks in defect tolerance with tissue injury. Imaging of the radial tie fiber (RTF) collagen structure in medial bovine menisci from fetal, juvenile, and adult specimens showed increasing heterogeneity, anisotropy, thickness, and density with skeletal development. Mechanical analysis showed that the tensile modulus in the radial direction did not change with skeletal development, though the resilience (in the radial direction) increased and the tolerance to defects in the circumferential direction decreased, in adult compared to fetal tissues. This loss of defect tolerance correlated with increased order in the RTF network in adult tissue. These data provide new insights into the role of the radial fiber network in meniscus function, will lead to improved clinical decision-making in the presence of a tear, and may improve engineering efforts to reproduce this critical load-bearing structure in the knee.
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