Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.
Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.
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DOI：
10.1016/j.jacc.2019.04.015
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发表时间：
2019-06-18
影响因子：
24
通讯作者：
Schlaich MP
中科院分区：
文献类型：
--
作者：
Kiuchi MG;Esler MD;Fink GD;Osborn JW;Banek CT;Böhm M;Denton KM;DiBona GF;Everett TH 4th;Grassi G;Katholi RE;Knuepfer MM;Kopp UC;Lefer DJ;Lohmeier TE;May CN;Mahfoud F;Paton JFR;Schmieder RE;Pellegrino PR;Sharabi Y;Schlaich MP
最近的三项肾去神经研究表明，与各自的假对照组相比，单纯药物治疗和药物治疗的高血压患者的动态血压显著降低。改进的试验设计，相关患者队列的选择，以及优化的介入程序可能有助于这些积极的发现。然而，仍然可以观察到肾去神经后血压反应的实质性变异性，这仍然是一个具有挑战性的重要问题。召开国际交感神经系统峰会是为了召集实验和临床医学的专家，讨论当前的证据基础、我们对神经相互作用的理解、程序方面的新发展、技术成功的监测等。确定该领域的相关趋势，并启动量身定制和联合的实验和临床研究工作，将有助于解决遗留问题，并提供急需的证据，以指导临床使用肾去神经治疗高血压和其他潜在的适应症。
Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.
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DOI：
10.1152/ajpregu.00408.2015
发表时间：
2016-02-01
影响因子：
2.8
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
2013-04
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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