Neuroanatomical and cognitive mediators of age-related differences in episodic memory.
Neuroanatomical and cognitive mediators of age-related differences in episodic memory.
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DOI：
10.1037/0894-4105.22.4.491
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发表时间：
2008-07
期刊：
影响因子：
2.4
通讯作者：
Raz, Naftali
中科院分区：
文献类型：
--
作者：
Head, Denise;Rodrigue, Karen M.;Kennedy, Kristen M.;Raz, Naftali
衰老与情景记忆的衰退有关。在这项研究中，作者使用路径分析框架来探讨大脑结构、执行功能和加工速度的差异在情景记忆年龄相关差异中的中介作用。测量区域脑容量（前额叶灰质和白色物质，尾状核，海马，视觉皮层），执行功能（工作记忆，抑制控制，任务转换，时间处理），处理速度，和情景记忆的年轻人和老年人的样本。正如预期的那样，年龄与局部脑容量和认知能力的减少有关。此外，神经和认知因素完全介导的情节记忆的年龄差异。海马萎缩直接影响情景记忆，而前额叶体积减少通过限制工作记忆和抑制控制影响情景记忆。与年龄相关的减慢预示着时间处理、工作记忆和抑制控制的效率降低。最后，较差的时间处理直接影响情景记忆。一旦考虑到这些因素，年龄对情景记忆没有直接影响。这些分析突出了多元方法的价值，了解认知和大脑老化的复杂关系。
Aging is associated with declines in episodic memory. In this study, the authors used a path analysis framework to explore the mediating role of differences in brain structure, executive functions, and processing speed in age-related differences in episodic memory. Measures of regional brain volume (prefrontal gray and white matter, caudate, hippocampus, visual cortex), executive functions (working memory, inhibitory control, task switching, temporal processing), processing speed, and episodic memory were obtained in a sample of young and older adults. As expected, age was linked to reduction in regional brain volumes and cognitive performance. Moreover, neural and cognitive factors completely mediated age differences in episodic memory. Whereas hippocampal shrinkage directly affected episodic memory, prefrontal volumetric reductions influenced episodic memory via limitations in working memory and inhibitory control. Age-related slowing predicted reduced efficiency in temporal processing, working memory, and inhibitory control. Lastly, poorer temporal processing directly affected episodic memory. No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
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DOI：
10.1076/1382-5585(199912)06:04;1-b;ft273
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