Haplotype-based genome-wide association studies for carcass and growth traits in chicken.
Haplotype-based genome-wide association studies for carcass and growth traits in chicken.
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基于单倍型的鸡屠体和生长性状的全基因组关联研究。
DOI：
10.1016/j.psj.2020.01.009
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发表时间：
2020-05
期刊：
影响因子：
4.4
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Zhang H;Shen LY;Xu ZC;Kramer LM;Yu JQ;Zhang XY;Na W;Yang LL;Cao ZP;Luan P;Reecy JM;Li H
There have been several genome-wide association study (GWAS) reported for carcass, growth, and meat traits in chickens. Most of these studies have been based on single SNPs GWAS. In contrast, haplotype-based GWAS reports have been limited. In the present study, 2 Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF) and genotyped with the chicken 60K SNP chip were used to perform a haplotype-based GWAS. The lean and fat chicken lines were selected for abdominal fat content for 11 yr. Abdominal fat weight was significantly different between the 2 lines; however, there was no difference for body weight between the lean and fat lines. A total of 132 haplotype windows were significantly associated with abdominal fat weight. These significantly associated haplotype windows were primarily located on chromosomes 2, 4, 8, 10, and 26. Seven candidate genes, including SHH, LMBR1, FGF7, IL16, PLIN1, IGF1R, and SLC16A1, were located within these associated regions. These genes may play important roles in the control of abdominal fat content. Two regions on chromosomes 3 and 10 were significantly associated with testis weight. These 2 regions were previously detected by the single SNP GWAS using this same resource population. TCF21 on chromosome 3 was identified as a potentially important candidate gene for testis growth and development based on gene expression analysis and the reported function of this gene. TCF12, which was previously detected in our SNP by SNP interaction analysis, was located in a region on chromosome 10 that was significantly associated with testis weight. Six candidate genes, including TNFRSF1B, PLOD1, NPPC, MTHFR, EPHB2, and SLC35A3, on chromosome 21 may play important roles in bone development based on the known function of these genes. In addition, several regions were significantly associated with other carcass and growth traits, but no candidate genes were identified. The results of the present study may be helpful in understanding the genetic mechanisms of carcass and growth traits in chickens.
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基本的螺旋 - 环螺旋转录因子TCF21是确定基因SRY的男性性别的下游靶标。
影响因子：
3.7
作者：
Bhandari RK;Sadler-Riggleman I;Clement TM;Skinner MK
通讯作者：
Skinner MK
DOI：
10.1186/1297-9686-45-36
发表时间：
2013-09-30
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Demeure O;Duclos MJ;Bacciu N;Le Mignon G;Filangi O;Pitel F;Boland A;Lagarrigue S;Cogburn LA;Simon J;Le Roy P;Le Bihan-Duval E
通讯作者：
Le Bihan-Duval E
影响因子：
5.8
作者：
Druet, Tom;Georges, Michel
通讯作者：
Georges, Michel
影响因子：
3.7
作者：
He Y;Li C;Amos CI;Xiong M;Ling H;Jin L
通讯作者：
Jin L
影响因子：
4.4
作者：
HILL, FW;DANSKY, LM
通讯作者：
DANSKY, LM