Photoacoustic tomography of blood oxygenation: A mini review.
Photoacoustic tomography of blood oxygenation: A mini review.
复制标题
血液氧合的光声断层扫描：迷你综述。
DOI：
10.1016/j.pacs.2018.05.001
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发表时间：
2018-06
期刊：
影响因子：
7.9
通讯作者：
Yao J
中科院分区：
文献类型：
--
作者：
Li M;Tang Y;Yao J
光声层析成像（PAT）是一种混合成像模式，结合了丰富的对比度的光学激发和深穿透的超声检测。PAT以其独特的光学吸收对比机制，对生物组织的功能和分子信息具有固有的敏感性，因此被广泛应用于临床前和临床研究。在PAT的许多功能中，测量血氧可以说是最重要的应用之一，并且已经在脑功能、肿瘤缺氧、伤口愈合和癌症治疗的光声研究中广泛进行。然而，生物组织的复杂光学条件，特别是强烈的波长依赖性光学衰减，长期以来一直阻碍PAT测量超过几毫米深度的血氧。已经开发了各种PAT方法来提高血氧测量的准确性，使用新颖的激光照明方案、氧敏荧光染料、综合数学模型或由互补成像模态提供的先验信息。这些新方法已经取得了令人兴奋的进展，但仍存在一些挑战。本文简要介绍了光声血氧测量的最新进展，比较了每种方法的优点和局限性，突出了它们的代表性应用，并讨论了未来发展面临的挑战。
Photoacoustic tomography (PAT) is a hybrid imaging modality that combines rich contrast of optical excitation and deep penetration of ultrasound detection. With its unique optical absorption contrast mechanism, PAT is inherently sensitive to the functional and molecular information of biological tissues, and thus has been widely used in preclinical and clinical studies. Among many functional capabilities of PAT, measuring blood oxygenation is arguably one of the most important applications, and has been widely performed in photoacoustic studies of brain functions, tumor hypoxia, wound healing, and cancer therapy. Yet, the complex optical conditions of biological tissues, especially the strong wavelength-dependent optical attenuation, have long hurdled the PAT measurement of blood oxygenation at depths beyond a few millimeters. A variety of PAT methods have been developed to improve the accuracy of blood oxygenation measurement, using novel laser illumination schemes, oxygen-sensitive fluorescent dyes, comprehensive mathematic models, or prior information provided by complementary imaging modalities. These novel methods have made exciting progress, while several challenges remain. This concise review aims to introduce the recent developments in photoacoustic blood oxygenation measurement, compare each method’s advantages and limitations, highlight their representative applications, and discuss the remaining challenges for future advances.
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