The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases.
The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases.
复制标题
胆红素在糖尿病，代谢综合征和心血管疾病中的作用。
DOI：
10.3389/fphar.2012.00055
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发表时间：
2012
影响因子：
5.6
通讯作者：
Vítek L
中科院分区：
文献类型：
--
作者：
Vítek L
胆红素是一个古老的四吡咯类化合物超家族，具有多种生物学功能。虽然几十年来胆红素被认为只是血红素分解代谢途径的废物，在最坏的情况下是一种潜在的有毒化合物;最近的数据令人信服地表明，血清胆红素水平轻度升高与氧化应激介导的疾病的患病率较低密切相关。事实上，血清胆红素一直显示与心血管疾病（CVD）以及CVD相关疾病和风险因素如动脉高血压、糖尿病、代谢综合征和肥胖负相关。此外，临床数据得到了来自体外和体内实验研究的证据的有力支持。这些数据不仅显示了胆红素本身的保护作用;而且还显示了血红素分解代谢途径的其他产物，如胆绿素和一氧化碳，以及其关键酶（血红素加氧酶和胆绿素还原酶）的保护作用;因此，进一步强调了该途径的生物学影响。本文综述了血红素分解代谢途径与心血管疾病以及糖尿病、代谢综合征、肥胖症等相关疾病之间的实验和临床证据。所有这些病理状况都是对人类文明的重大威胁，是发达国家的主要杀手，发病率稳步上升。因此，寻找这些疾病的新标记物以及新的治疗方式来扭转这种不利的情况是极其重要的。血红素分解代谢途径似乎满足诊断目的和潜在治疗干预的标准。
Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only a waste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases (CVD), as well as to CVD-related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity. In addition, the clinical data are strongly supported by evidence arising from both in vitro and in vivo experimental studies. This data not only shows the protective effects of bilirubin per se; but additionally, of other products of the heme catabolic pathway such as biliverdin and carbon monoxide, as well as its key enzymes (heme oxygenase and biliverdin reductase); thus, further underlining the biological impacts of this pathway. In this review, detailed information on the experimental and clinical evidence between the heme catabolic pathway and CVD, and those related diseases such as diabetes, metabolic syndrome, and obesity is provided. All of these pathological conditions represent an important threat to human civilization, being the major killers in developed countries, with a steadily increasing prevalence. Thus, it is extremely important to search for novel markers of these diseases, as well as for novel therapeutic modalities to reverse this unfavorable situation. The heme catabolic pathway seems to fulfill the criteria for both diagnostic purposes as well as for potential therapeutical interventions.
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影响因子：
5.7
作者：
Huang, Shao-Sung;Huang, Po-Hsun;Chen, Jaw-Wen
通讯作者：
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DOI：
10.1161/atvbaha.110.211789
发表时间：
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作者：
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作者：
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