D1 receptors in the nucleus accumbens-shell, but not the core, are involved in mediating ethanol-seeking behavior of alcohol-preferring (P) rats.
D1 receptors in the nucleus accumbens-shell, but not the core, are involved in mediating ethanol-seeking behavior of alcohol-preferring (P) rats.
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DOI：
10.1016/j.neuroscience.2015.03.030
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发表时间：
2015-06-04
期刊：
影响因子：
3.3
通讯作者：
Rodd ZA
中科院分区：
文献类型：
--
作者：
Hauser SR;Deehan GA Jr;Dhaher R;Knight CP;Wilden JA;McBride WJ;Rodd ZA
Clinical and preclinical research suggest that activation of the mesolimbic dopamine (DA) system is involved in mediating the rewarding actions of drugs of abuse, as well as promoting drug-seeking behavior. Inhibition of DA D1 receptors in the nucleus accumbens (Acb) can reduce ethanol (EtOH)-seeking behavior of non-selective rats triggered by environmental context. However, to date, there has been no research on the effects D1 receptor agen ts on EtOH-seeking behavior of high alcohol preferring (P) rats following prolonged abstinence. The objective of the present study was to examine the effects of microinjecting the D1 antagonist SCH 23390 or the D1 agonist A-77636 into the Acb shell or Acb core on spontaneous recovery of EtOH-seeking behavior. After 10 weeks of concurrent access to EtOH and water, P rats underwent 7 extinction sessions (EtOH and water withheld), followed by 2 weeks in their home cages without access to EtOH or operant sessions. In the 2nd week of the home cage phase, rats were bilaterally implanted with guide cannula aimed at the Acb shell or Acb core; rats were allowed 7 days to recover before EtOH-seeking was assessed by the Pavlovian spontaneous recovery (PSR) model. Administration of SCH23390 (1 μg/side) into the Acb shell inhibited responding on the EtOH lever, whereas administration of A-77636 (0.125 μg/side) increased responding on the EtOH lever. Microinfusion of D1 receptor agents into the Acb core did not alter responding on the EtOH lever. Responses on the water lever were not altered by any of the treatments. The results suggest that activation of D1 receptors within the Acb shell, but not Acb core, are involved in mediating PSR of EtOH-seeking behavior of P rats.
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DOI：
10.1111/j.1460-9568.2008.06517.x
发表时间：
2008-12
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Chaudhri N;Sahuque LL;Cone JJ;Janak PH
通讯作者：
Janak PH
DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.3
作者：
Funk, D;Li, Z;Lê, AD
通讯作者：
Lê, AD
DOI：
10.1124/jpet.300.3.882
发表时间：
2002-03-01
影响因子：
3.5
作者：
Liu, X;Weiss, F
通讯作者：
Weiss, F
影响因子：
25
作者：
Ito, R;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ