A retrospective review of non‑intestinal‑type adenocarcinoma of nasal cavity and paranasal sinus.
A retrospective review of non‑intestinal‑type adenocarcinoma of nasal cavity and paranasal sinus.
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DOI：
10.3892/ol.2023.13718
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发表时间：
2023-03
期刊：
影响因子：
2.9
通讯作者：
Chen B
中科院分区：
文献类型：
--
作者：
Li J;Li B;Xu J;Wang H;Gao Q;Ye F;Xu Y;Wu S;Cheng S;Lu Y;Guan J;Chen B
鼻腔和鼻窦非肠腺癌（n-ITAC）是一种异质性肿瘤，以往的研究很少报道。大多数高级别n-ITAC预后较差，缺乏经典的治疗策略。本研究使用南方医科大学南方医院2000年1月至2020年6月期间的PACS系统进行检查，检索关键词“n-ITAC”并选择病理。总共搜索了 15 名连续患者。最后，本研究总共分析了 12 名 n-ITAC 患者。平均随访时间为47个月。对于低级别（G1）肿瘤，1年和3年总生存（OS）率分别为100和85.7%，而对于高级别（G3）肿瘤，1年和3年OS率分别为80.0和20.0%。病理分级可能是不良预后因素（P=0.077）。手术组的OS明显优于非手术组（3年OS为63.6 vs. 0%，P=0.0009）。手术是不可缺少的治疗手段。切缘阳性患者的OS低于切缘阴性患者（P=0.186），提示完全切除可能是预后因素之一。有高危因素的患者接受放射治疗。对于切缘阳性或未手术的患者，放射剂量为 66-70 Gy/33F；对于切缘阴性的患者，放射剂量为 60 Gy/28F。大多数患者接受了颈部区域的预防性照射。因此，病理性高级别n-ITAC的预后较差。手术是n-ITAC最有效且不可或缺的治疗方法。对于有高危因素的患者，手术联合放疗可能是一种合理的治疗方法。就放疗覆盖范围而言，南方医科大学南方医院多采用原发肿瘤联合淋巴结引流区，若手术切缘阴性则可减少放疗总剂量。
Non-intestinal adenocarcinoma of nasal cavity and paranasal sinuses (n-ITAC) is a heterogeneous tumor, which has rarely been reported in previous studies. Most high-grade n-ITAC has poor prognosis and there is a lack of classic therapeutic strategy. The present study examined using the PACS system of Nanfang Hospital of Southern Medical University between January 2000 and June 2020. It searched the keyword ‘n-ITAC’ and selected pathology. A total of 15 consecutive patients were searched. Finally, the present study analyzed a total of 12 n-ITAC patients. The follow-up time was 47 months on average. For low-grade (G1) tumors, 1 and 3-year overall survival (OS) rate were 100 and 85.7% respectively, while for high-grade (G3) tumors, 1 and 3-year OS rates were 80.0 and 20.0% respectively. Pathological grade may be an adverse prognostic factor (P=0.077). The OS of the surgery group was significantly superior to that of the non-surgery group (3-year OS was 63.6 vs. 0%, P=0.0009). Surgery is an indispensable means of treatment. The OS of patients with positive incisal margin was lower compared with that of patients with negative margin (P=0.186), suggesting that complete resection may be one of the prognostic factors. Patients with high risk factors received radiotherapy. The radiation dose was 66–70 Gy/33F for patients with positive margin or non-operation and was 60 Gy/28F for those with negative margin. Most of the patients received prophylactic irradiation of cervical area. Therefore, the prognosis of pathological high-grade n-ITAC is poor. Surgery is the most effective and an indispensable treatment for n-ITAC. For patients with high risk factors, surgery combined with radiotherapy may be a reasonable treatment. With regard to the cover range of radiotherapy, the primary tumor combined with lymph node drainage area is often used in Nanfang Hospital of Southern Medical University and the total dose of radiotherapy can be reduced if the surgical margin is negative.
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影响因子：
6.2
作者：
Robin TP;Jones BL;Gordon OM;Phan A;Abbott D;McDermott JD;Goddard JA;Raben D;Lanning RM;Karam SD
通讯作者：
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DOI：
10.1002/hed.24144
发表时间：
2016-04-01
影响因子：
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DOI：
10.1002/hed.20168
发表时间：
2005-05-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
2.1
作者：
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通讯作者：
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