Neural mechanism of placebo effects and cognitive reappraisal in emotion regulation
Neural mechanism of placebo effects and cognitive reappraisal in emotion regulation
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安慰剂效应的神经机制和情绪调节中的认知重评
DOI：
10.1016/j.pnpbp.2012.10.020
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发表时间：
2013-01
影响因子：
5.6
通讯作者：
Jing Luo
中科院分区：
文献类型：
--
作者：
Wencai Zhang;Jianyou Guo;Jianxin Zhang;Jing Luo
本研究比较了基于学习的安慰剂效应和基于认知的重评效应，揭示了这两种情绪调节机制共同而独特的神经机制。首先，通过进行行为实验来测试焦虑缓解效果。接下来，具有最高安慰剂或再评价效应的参与者被选择用于功能性磁共振成像实验。结果表明：（2）安慰剂效应激活了左侧膝下扣带回，而重评激活了右侧背侧前额叶皮层（PFC）和左侧下PFC。我们的结果表明，基于学习的安慰剂效应和基于认知的重评具有共同的焦虑缓解效应。安慰剂效应主要依赖于扣带回-杏仁核的直接通路来调节情绪，而重评效应可能既依赖于背侧PFC-扣带回-杏仁核的间接通路，也依赖于腹侧PFC-杏仁核的直接通路来调节情绪。
The present study compared learning-based placebo effect and cognition-based reappraisal, to reveal the common and unique neural mechanisms between the two emotion regulations. First, the anxiety-relieving effect was tested by conducting a behavioral experiment. Next, the participants with the highest placebo or reappraisal effect were selected for the functional magnetic resonance imaging experiments. The results indicated that: (1) they both attenuated activity in the right amygdala and right insula, and (2) placebo effect activated the left subgenual cingulate whereas reappraisal activated the right dorsal prefrontal cortex (PFC) and the left inferior PFC. Our results show that learning-based placebo effect and cognition-based reappraisal have common anxiety-relieving effects. The placebo effect mainly depends on direct pathway subgenual cingulate–amygdala to regulate emotions, whereas the reappraisal may rely on both indirect pathways, such as the dorsal PFC–subgenual cingulate–amygdala, and direct pathways, such as the ventral lateral PFC–amygdala to regulate emotions.
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影响因子：
7.4
作者：
Watson A;El-Deredy W;Iannetti GD;Lloyd D;Tracey I;Vogt BA;Nadeau V;Jones AK
通讯作者：
Jones AK
可转移安慰剂抗焦虑作用的后续功能磁共振成像研究。
影响因子：
3.7
作者：
Weicai Zhang;Shaozhen Qin;Jianyou Guo;Jing Luo
通讯作者：
Jing Luo
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
1.7
作者：
Yang TT;Simmons AN;Matthews SC;Tapert SF;Frank GK;Bischoff-Grethe A;Lansing AE;Wu J;Paulus MP
通讯作者：
Paulus MP
DOI：
10.1073/pnas.1200782109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Rodriguez-Romaguera, Jose;Do Monte, Fabricio H. M.;Quirk, Gregory J.
通讯作者：
Quirk, Gregory J.