Assessment of fatigue-related biochemical alterations in a rat swimming model under hypoxia
Assessment of fatigue-related biochemical alterations in a rat swimming model under hypoxia
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缺氧条件下大鼠游泳模型疲劳相关生化变化的评估
DOI：
10.1242/jeb.199711
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发表时间：
2019-01
影响因子：
2.8
通讯作者：
Huang Qing Yuan
中科院分区：
文献类型：
--
作者：
Shan Fabo;Yang Tao;Li Junxia;Huang Qing Yuan
摘要 众所周知，运动引起的疲劳在缺氧后会加剧，并且可能由中枢和/或外周机制引起。为了评估缺氧条件下外周和中枢因素对运动性疲劳的相对影响，建立了一次力竭游泳引起的疲劳大鼠模型，并比较了常氧和严重缺氧条件下与疲劳相关的生化变化。将大鼠随机分为四组：常氧休息组（NR）、力竭游泳组（NE）、缺氧休息组（HR）和力竭游泳组（HE）。缺氧情况下，体重2.5%的游泳至力竭时间缩短。 HE组的血乳酸水平、腓肠肌pAMPK/AMPK比值均低于NE组，腓肠肌糖原含量高于NE组，均表明HE组的周围疲劳程度低于NE组。同时，常氧下力竭游泳导致纹状体3,4-二羟基苯乙酸（DOPAC）显着增加，而在严重缺氧下这种增加几乎减弱，表明缺氧可能会加剧运动引起的中枢疲劳。这些生化变化表明，从常氧到严重缺氧，外周和中枢因素对运动性疲劳的相对贡献发生变化，中枢性疲劳可能在缺氧下运动表现下降中起主导作用。摘要：缺氧暴露改变了外周和中枢因素对运动引起的疲劳的相对贡献，而中枢疲劳可能在缺氧下运动表现下降中起主要作用。
ABSTRACT It is well known that exercise-induced fatigue is exacerbated following hypoxia exposure and may arise from central and/or peripheral mechanisms. To assess the relative contribution of peripheral and central factors to exercise-induced fatigue under hypoxia, a rat model of fatigue by a bout of exhaustive swimming was established and fatigue-related biochemical changes in normoxic and severe hypoxic conditions were compared. Rats were randomly divided into four groups: normoxia resting (NR), exhaustive swimming (NE), hypoxia resting (HR) and exhaustive swimming (HE). The swimming time to exhaustion with a weight equal to 2.5% of their body weight reduced under hypoxia. There were lower blood lactate levels, lower gastrocnemius pAMPK/AMPK ratios and higher gastrocnemius glycogen contents in the HE than in the NE groups, which all suggested a lower degree of peripheral fatigue in the HE group than in the NE group. Meanwhile, there was a significant increase in striatal 3,4-dihydroxyphenylacetic acid (DOPAC) caused by exhaustive swimming under normoxia, whereas this increase was almost blunted under severe hypoxia, indicating that hypoxia might exacerbate exercise-induced central fatigue. These biochemical changes suggest that from normoxia to severe hypoxia, the relative contribution of peripheral and central factors to exercise-induced fatigue alters, and central fatigue may play a predominant role in the decline in exercise performance under hypoxia. Summary: Hypoxia exposure alters the relative contribution of peripheral and central factors to exercise-induced fatigue, and central fatigue may play a predominant role in the decline in exercise performance under hypoxia.
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影响因子：
3.7
作者：
Pescador N;Villar D;Cifuentes D;Garcia-Rocha M;Ortiz-Barahona A;Vazquez S;Ordoñez A;Cuevas Y;Saez-Morales D;Garcia-Bermejo ML;Landazuri MO;Guinovart J;del Peso L
通讯作者：
del Peso L
DOI：
--
发表时间：
1986-12
期刊：
Federation proceedings
影响因子：
--
作者：
J. West
通讯作者：
J. West
影响因子：
3
作者：
Smirmaul BP;de Moraes AC;Angius L;Marcora SM
通讯作者：
Marcora SM
影响因子：
6.1
作者：
HEYES, MP;GARNETT, ES;COATES, G
通讯作者：
COATES, G
DOI：
10.1046/j.1365-201x.1997.00118.x
发表时间：
1997-04-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Meeusen, R;Smolders, I;Michotte, Y
通讯作者：
Michotte, Y