Antibiotic resistance in probiotic bacteria.
Antibiotic resistance in probiotic bacteria.
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DOI：
10.3389/fmicb.2013.00202
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发表时间：
2013
影响因子：
5.2
通讯作者：
Margolles A
中科院分区：
文献类型：
--
作者：
Gueimonde M;Sánchez B;G de Los Reyes-Gavilán C;Margolles A
益生菌是活的微生物，当给予足够的量时，对宿主的健康有益。主要的益生菌是属于乳杆菌属和双歧杆菌属的菌株，尽管其他代表，如芽孢杆菌或大肠杆菌菌株也被使用。乳酸菌和双歧杆菌是人类肠道微生物群的两种常见的居民。此外，一些菌种在食品发酵过程中用作发酵剂，或在食品工业中用作辅助培养物。除了一些例外，当突变或内在耐药机制导致耐药表型时，这些有益微生物的抗生素耐药性本身并不构成安全问题。事实上，一些具有内在抗生素耐药性的益生菌菌株可能有助于在抗生素治疗后恢复肠道微生物群。然而，特定的抗生素耐药决定因素携带在移动遗传元件上，如四环素耐药基因，通常在典型的益生菌属中检测到，并构成潜在食物或肠道病原体的耐药库，因此代表了严重的安全问题。
Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. The main probiotic bacteria are strains belonging to the genera Lactobacillus and Bifidobacterium, although other representatives, such as Bacillus or Escherichia coli strains, have also been used. Lactobacillus and Bifidobacterium are two common inhabitants of the human intestinal microbiota. Also, some species are used in food fermentation processes as starters, or as adjunct cultures in the food industry. With some exceptions, antibiotic resistance in these beneficial microbes does not constitute a safety concern in itself, when mutations or intrinsic resistance mechanisms are responsible for the resistance phenotype. In fact, some probiotic strains with intrinsic antibiotic resistance could be useful for restoring the gut microbiota after antibiotic treatment. However, specific antibiotic resistance determinants carried on mobile genetic elements, such as tetracycline resistance genes, are often detected in the typical probiotic genera, and constitute a reservoir of resistance for potential food or gut pathogens, thus representing a serious safety issue.
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影响因子：
4.4
作者：
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通讯作者：
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DOI：
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DOI：
10.1016/j.ijfoodmicro.2012.01.018
发表时间：
2012-04-16
影响因子：
5.4
作者：
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通讯作者：
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