Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas.
Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas.
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环状RNA在癌症和非癌症中的扩大无帽翻译和新兴功能
DOI：
10.1186/s12943-021-01484-7
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发表时间：
2022-01-07
期刊：
影响因子：
37.3
通讯作者：
Bai J
中科院分区：
文献类型：
--
作者：
Wang Y;Wu C;Du Y;Li Z;Li M;Hou P;Shen Z;Chu S;Zheng J;Bai J
环状RNA（circRNA）被分类为非编码RNA，因为它们缺乏帽依赖性翻译所必需的5'端帽和3'端聚腺苷酸尾。然而，通过高通量RNA测序与多核糖体分析重叠鉴定的越来越多的翻译circRNA表明这一规则正在被打破。CircRNA可以以帽非依赖性机制翻译，包括IRES（内部核糖体进入位点）起始模式、MIRES（m6A内部核糖体进入位点）起始模式和滚动翻译机制（RCA）。CircRNA编码的蛋白具有与宿主蛋白相似或不同的多种功能。此外，它们与人类疾病的调节有关，包括癌和非癌。与CircRNA相关的翻译组学和蛋白质组学越来越受到人们的关注。本文综述了circRNA翻译的研究进展和独特性，并重点介绍了circRNA翻译组学的最新机制和调控。此外，我们总结了circRNA衍生蛋白在人类疾病中的广泛功能和机制，这有助于更好地理解复杂的非经典circRNA翻译组学和蛋白质组学及其在人类疾病中的治疗潜力。
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated circRNAs identified through high-throughput RNA sequencing overlapping with polysome profiling indicate that this rule is being broken. CircRNAs can be translated in cap-independent mechanism, including IRES (internal ribosome entry site)-initiated pattern, MIRES (m6A internal ribosome entry site) -initiated patterns, and rolling translation mechanism (RCA). CircRNA-encoded proteins harbour diverse functions similar to or different from host proteins. In addition, they are linked to the modulation of human disease including carcinomas and noncarcinomas. CircRNA-related translatomics and proteomics have attracted increasing attention. This review discusses the progress and exclusive characteristics of circRNA translation and highlights the latest mechanisms and regulation of circRNA translatomics. Furthermore, we summarize the extensive functions and mechanisms of circRNA-derived proteins in human diseases, which contribute to a better understanding of intricate noncanonical circRNA translatomics and proteomics and their therapeutic potential in human diseases.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
circRNA生物合成的调控
影响因子：
4.1
作者：
Chen, Ling-Ling;Yang, Li
通讯作者：
Yang, Li
影响因子：
4.6
作者：
Abe N;Matsumoto K;Nishihara M;Nakano Y;Shibata A;Maruyama H;Shuto S;Matsuda A;Yoshida M;Ito Y;Abe H
通讯作者：
Abe H
影响因子：
20.1
作者：
Du, William W.;Xu, Jindong;Yang, Burton B.
通讯作者：
Yang, Burton B.