Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study.
Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study.
复制标题
DOI：
10.1080/01635581.2020.1743870
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Koh WP
中科院分区：
文献类型：
--
作者：
Wang Y;Jafar TH;Jin A;Yuan JM;Koh WP
流行病学研究已分别证明，肾结石患者膳食中锌的摄入量可能较高，患肾癌的风险也较高。我们首次前瞻性评估了膳食锌和其他微量元素与肾癌风险的关联。我们使用了前瞻性新加坡华人健康研究的数据，该研究招募了 1993 年至 1998 年间居住在新加坡的 63,257 名成年华人。使用经过验证的食物频率调查问卷和新加坡食物成分数据库来计算锌、铜和锰的摄入量。我们通过与全国癌症登记处联系来确定癌症病例，并使用 Cox 比例风险模型来计算与肾癌风险关联的风险比 (HR) 和 95% 置信区间 (CI)。中位随访 20.1 年后，共有 229 例肾癌病例发生。膳食锌摄入量与较高的肾癌风险呈正相关；比较锌摄入量极端四分位数的 HR 为 1.74（95% CI：1.02–2.97；P 趋势=0.033）。相反，铜和锰的摄入量与肾癌风险无关。膳食锌与肾癌风险之间的正相关表明锌可能与肾癌发生有关。
Epidemiological studies have demonstrated separately that patients with kidney stone may have higher dietary intake of zinc and higher risk of developing kidney cancer. We prospectively assessed the associations of dietary zinc and other trace elements with kidney cancer risk for the first time. We used data from the prospective Singapore Chinese Health Study that recruited 63,257 adult Chinese residing in Singapore between 1993 and 1998. A validated food frequency questionnaire and the Singapore Food Composition Database was used to compute the values of intake for zinc, copper and manganese. We identified incident cancer cases via linkage with nationwide cancer registry, and used Cox proportional hazard models to compute hazard ratio (HR) and 95% confidence interval (CI) for the association with kidney cancer risk. There were 229 incident kidney cancer cases after median follow-up of 20.1 years. Dietary zinc intake was positively associated with higher kidney cancer risk; the HR comparing the extreme quartiles of zinc intake was 1.74 (95% CI: 1.02–2.97; P-trend=0.033). Conversely, intakes of copper and manganese were not associated with kidney cancer risk. The positive association between dietary zinc and risk of kidney cancer suggests that zinc may be implicated in renal carcinogenesis.
登录
查看更多内容
影响因子：
10.6
作者：
Jeong, Jeeyon;Eide, David J.
通讯作者：
Eide, David J.
影响因子：
120.7
作者：
CHANDRA, RK
通讯作者：
CHANDRA, RK
影响因子：
8.8
作者：
van de Pol, Jeroen A. A.;van den Brandt, Piet A.;Schouten, Leo J.
通讯作者：
Schouten, Leo J.
影响因子：
6.6
作者：
Johnson, Aaron R.;Munoz, Alejandro;Jarrard, David F.
通讯作者：
Jarrard, David F.
影响因子：
2
作者：
KOMLEH K;HADA P;SINGH P P
通讯作者：
SINGH P P