Recent Advances in the Development and Antimicrobial Applications of Metal-Phenolic Networks.
Recent Advances in the Development and Antimicrobial Applications of Metal-Phenolic Networks.
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金属-酚醛网络的开发及抗菌应用研究进展。
DOI：
10.1002/advs.202202684
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发表时间：
2022-09
期刊：
影响因子：
15.1
通讯作者：
Guo, Jinshan
中科院分区：
文献类型：
--
作者：
Li, Yue;Miao, Yong;Yang, Lunan;Zhao, Yitao;Wu, Keke;Lu, Zhihui;Hu, Zhiqi;Guo, Jinshan
由于抗生素的滥用和多重耐药微生物的出现，医疗器械和相关生物材料在使用过程中面临微生物感染的高风险，给患者和医疗保健系统带来了沉重的负担。金属-酚类网络（MPN）是近年来逐渐发展起来的一种新兴的有机-无机混合网络体系，它利用酚类配体与金属离子之间的配位作用，表现出优异的抗炎、抗氧化、抗菌等多功能性能。此外，MPN由于其容易的合成过程、优异的生物相容性以及由多酚和金属离子带来的优异的抗微生物特性而在抗微生物感染中受到广泛关注。本文综述了基于MPN的不同类型生物材料（纳米颗粒、涂层、胶囊、水凝胶）及其制备策略，并对其在生物医学领域（如抗菌、抗菌、皮肤修复、骨再生、医疗器械等）突出显示。本文综述了近年来金属-酚醛网络（MPN）作为生物材料的优异抗菌性能。主要介绍了MPN的主要成分和不同形式的MPN生物材料，并综述了MPN基生物材料在皮肤修复、骨再生、生物器件等领域的抗菌应用。
Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal–phenolic networks (MPNs), an emerging organic–inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti‐inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted. This review discusses the outstanding antibacterial performance of metal–phenolic networks (MPNs) as biomaterials in recent years. The main components of MPNs and different forms of MPNs biomaterials are mainly introduced, and the antibacterial applications of MPNs‐based biomaterials in skin repair, bone regeneration, biodevices, and other fields are summarized.
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