Genetic Dissection of the Host Tropism of Human-Tropic Pathogens.
Genetic Dissection of the Host Tropism of Human-Tropic Pathogens.
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DOI：
10.1146/annurev-genet-112414-054823
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发表时间：
2015
影响因子：
11.1
通讯作者：
Ploss A
中科院分区：
文献类型：
--
作者：
Douam F;Gaska JM;Winer BY;Ding Q;von Schaewen M;Ploss A
传染病是全球第二大死亡原因。尽管一些病原体的宿主多向性使得它们在动物模型中的操纵成为可能，但许多病毒、细菌、真菌和寄生虫的人类限制性向性严重阻碍了我们对这些病原体的了解。因此，揭示此类病原体的狭义向性背后的遗传基础对于了解其感染机制和发病机制至关重要。此外，这种基因解剖对于产生允许的动物模型至关重要，这些动物模型可以作为开发针对具有挑战性的人类病原体的疗法或疫苗的关键工具。在这篇综述中，我们描述了用于揭示调节病原体宿主向性的遗传基础及其与研究几种重要人类病原体向性的相关性的不同实验方法。最后，我们讨论了当前和未来使用这些知识来生成允许这些病原体的转基因动物模型。
Infectious diseases are the second leading cause of death worldwide. Although the host multitropism of some pathogens has rendered their manipulation possible in animal models, the human-restricted tropism of numerous viruses, bacteria, fungi, and parasites has seriously hampered our understanding of these pathogens. Hence, uncovering the genetic basis underlying the narrow tropism of such pathogens is critical for understanding their mechanisms of infection and pathogenesis. Moreover, such genetic dissection is essential for the generation of permissive animal models that can serve as critical tools for the development of therapeutics or vaccines against challenging human pathogens. In this review, we describe different experimental approaches utilized to uncover the genetic foundation regulating pathogen host tropism as well as their relevance for studying the tropism of several important human pathogens. Finally, we discuss the current and future uses of this knowledge for generating genetically modified animal models permissive for these pathogens.
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影响因子：
6.7
作者：
Bility MT;Cheng L;Zhang Z;Luan Y;Li F;Chi L;Zhang L;Tu Z;Gao Y;Fu Y;Niu J;Wang F;Su L
通讯作者：
Su L
影响因子：
15.1
作者：
Do Carmo S;Cuello AC
通讯作者：
Cuello AC
影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
影响因子：
64.8
作者：
通讯作者：
--
大致中和抗体消除了乙型肝炎病毒感染。
影响因子：
17.1
作者：
de Jong YP;Dorner M;Mommersteeg MC;Xiao JW;Balazs AB;Robbins JB;Winer BY;Gerges S;Vega K;Labitt RN;Donovan BM;Giang E;Krishnan A;Chiriboga L;Charlton MR;Burton DR;Baltimore D;Law M;Rice CM;Ploss A
通讯作者：
Ploss A