Cyanotoxins and the Nervous System.

Cyanotoxins and the Nervous System.
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蓝藻毒素和神经系统。

DOI:
10.3390/toxins13090660
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发表时间:
2021-09-16
期刊:
影响因子:
4.2
通讯作者:
Stommel EW
Stommel EW
中科院分区:
医学2区
文献类型:
--
作者:
Metcalf JS;Tischbein M;Cox PA;Stommel EW

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蓝细菌能够产生多种生物活性化合物,其中许多被认为是毒素。尽管蓝藻暴露会产生许多毒理学结果,但本综述旨在检查那些影响中枢神经系统 (CNS) 或具有神经毒理学特性的毒理学结果。此类暴露可能是急性的,也可能是慢性的,我们详细介绍了有关中枢神经系统进入、检测和补救的问题。接触可能通过多种媒介发生,但越来越多地,通过吸入空气接触可能具有更大的意义,需要进一步调查。尽管蓝藻毒素传统上是根据其主要毒性模式进行分类的,但越来越多的证据表明,某些蓝藻毒素还具有神经毒性特性,包括已知的蓝藻毒素和未知化合物。此外,越来越多的人认为,长期长期接触这些化合物会对人类健康产生不利影响。
Cyanobacteria are capable of producing a wide range of bioactive compounds with many considered to be toxins. Although there are a number of toxicological outcomes with respect to cyanobacterial exposure, this review aims to examine those which affect the central nervous system (CNS) or have neurotoxicological properties. Such exposures can be acute or chronic, and we detail issues concerning CNS entry, detection and remediation. Exposure can occur through a variety of media but, increasingly, exposure through air via inhalation may have greater significance and requires further investigation. Even though cyanobacterial toxins have traditionally been classified based on their primary mode of toxicity, increasing evidence suggests that some also possess neurotoxic properties and include known cyanotoxins and unknown compounds. Furthermore, chronic long-term exposure to these compounds is increasingly being identified as adversely affecting human health.
DOI: 10.1186/1471-2377-9-s1-s3
发表时间: 2009-06-12
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