The Role of the Clinically Obtained Acoustic Reflex as a Research Tool for Subclinical Hearing Pathologies.
The Role of the Clinically Obtained Acoustic Reflex as a Research Tool for Subclinical Hearing Pathologies.
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DOI：
10.1177/2331216520972860
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发表时间：
2020-01
影响因子：
2.7
通讯作者：
Prendergast G
中科院分区：
文献类型：
--
作者：
Causon A;Munro KJ;Plack CJ;Prendergast G
声反射（AR）显示出作为啮齿动物耳蜗突触病存在的客观测试的希望。与没有耳鸣的人相比，AR在耳鸣患者中也被证明是减少的。本研究的目的是双重的：（a）确定AR强度（量化为阈值和生长）是否随寿命噪声暴露而变化，从而提供对突触病程度的估计;（B）确定当使用AR作为定量测量而不仅仅是存在/不存在响应时应考虑哪些因素。AR阈值和生长功能进行了测量，使用同侧和对侧，宽带和音调激发器在成年人正常听力和不同水平的终身噪声暴露。仅使用临床标准226 Hz探头音。AR阈值和增长不相关的终身噪声暴露，这表明常规的临床AR措施是不是一个敏感的措施时，调查噪声暴露在听力正常的听众的影响。我们的二次探索性分析显示，AR阈值和生长与中耳顺应性显著相关。具有较高中耳顺应性的听众（尽管仍在临床正常范围内）表现出较低的AR阈值和较陡的AR生长功能。此外，中耳顺应性在性别之间存在差异，男性的中耳顺应性值高于女性。因此，可能有必要将中耳顺应性值纳入任何使用AR作为听觉功能估计的分析中。
The acoustic reflex (AR) shows promise as an objective test for the presence of cochlear synaptopathy in rodents. The AR has also been shown to be reduced in humans with tinnitus compared to those without. The aim of the present study was twofold: (a) to determine if AR strength (quantified as both threshold and growth) varied with lifetime noise exposure, and thus provided an estimate of the degree of synaptopathy and (b) to identify which factors should be considered when using the AR as a quantitative measure rather than just present/absent responses. AR thresholds and growth functions were measured using ipsilateral and contralateral, broadband and tonal elicitors in adults with normal hearing and varying levels of lifetime noise exposure. Only the clinical standard 226 Hz probe tone was used. AR threshold and growth were not related to lifetime noise exposure, suggesting that routine clinical AR measures are not a sensitive measure when investigating the effects of noise exposure in audiometrically normal listeners. Our secondary, exploratory analyses revealed that AR threshold and growth were significantly related to middle-ear compliance. Listeners with higher middle-ear compliance (though still in the clinically normal range) showed lower AR thresholds and steeper AR growth functions. Furthermore, there was a difference in middle-ear compliance between the sexes, with males showing higher middle-ear compliance values than females. Therefore, it may be necessary to factor middle-ear compliance values into any analysis that uses the AR as an estimate of auditory function.
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影响因子：
4.3
作者：
Grinn SK;Wiseman KB;Baker JA;Le Prell CG
通讯作者：
Le Prell CG
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
影响因子：
3.7
作者：
Liberman MC;Epstein MJ;Cleveland SS;Wang H;Maison SF
通讯作者：
Maison SF
影响因子：
2.7
作者：
Grose JH;Buss E;Hall JW 3rd
通讯作者：
Hall JW 3rd
影响因子：
3.3
作者：
Bharadwaj, Hari M.;Mai, Alexandra R.;Shinn-Cunningham, Barbara G.
通讯作者：
Shinn-Cunningham, Barbara G.