The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review.
The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review.
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DOI：
10.3390/ijms222010911
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发表时间：
2021-10-09
影响因子：
5.6
通讯作者：
Chen CC
中科院分区：
文献类型：
--
作者：
Wu CY;Wu JD;Chen CC
卵巢畸胎瘤是迄今为止最常见的卵巢生殖细胞肿瘤。大多数畸胎瘤是良性的，除非发生体细胞转化。畸胎瘤的名称是指向体细胞型细胞群分化的肿瘤。最近的研究表明卵巢畸胎瘤与抗n -甲基- d -天冬氨酸受体（抗nmdar）脑炎（一种罕见且研究不足的副肿瘤神经综合征（PNS））之间存在显著关联。在畸胎瘤中，成熟畸胎瘤被认为与那些神经损伤有更大的相关性。PNS被描述为由潜在的远处肿瘤引发的神经功能缺陷，而抗NMDAR脑炎的特征是复杂的神经精神综合征和脑脊液中存在针对NMDAR GluN1亚基的自身抗体。本文综述了抗nmdar脑炎与卵巢畸胎瘤之间关系的最新报道。重点讨论了其发病的分子途径、最新的发病机制和疾病模型。我们希望对这一问题进行深入的综述，从而更好地了解其流行病学、诊断方法和治疗策略。
Ovarian teratomas are by far the most common ovarian germ cell tumor. Most teratomas are benign unless a somatic transformation occurs. The designation of teratoma refers to a neoplasm that differentiates toward somatic-type cell populations. Recent research shows a striking association between ovarian teratomas and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a rare and understudied paraneoplastic neurological syndrome (PNS). Among teratomas, mature teratomas are thought to have a greater relevance with those neurological impairments. PNS is described as a neurologic deficit triggered by an underlying remote tumor, whereas anti-NMDAR encephalitis is characterized by a complex neuropsychiatric syndrome and the presence of autoantibodies in cerebral spinal fluid against the GluN1 subunit of the NMDAR. This review aims to summarize recent reports on the association between anti-NMDAR encephalitis and ovarian teratoma. In particular, the molecular pathway of pathogenesis and the updated mechanism and disease models would be discussed. We hope to provide an in-depth review of this issue and, therefore, to better understand its epidemiology, diagnostic approach, and treatment strategies.
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