How complete are current yeast and human protein-interaction networks?
How complete are current yeast and human protein-interaction networks?
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DOI:
10.1186/gb-2006-7-11-120
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发表时间:
2006
期刊:
影响因子:
12.3
通讯作者:
Marcotte EM
中科院分区:
文献类型:
--
作者:
Hart GT;Ramani AK;Marcotte EM
How can protein-interaction networks can be made more complete? We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
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