Structural connectivity of the amygdala in young adults with autism spectrum disorder.
Structural connectivity of the amygdala in young adults with autism spectrum disorder.
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DOI：
10.1002/hbm.23915
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Clark CA
中科院分区：
文献类型：
--
作者：
Gibbard CR;Ren J;Skuse DH;Clayden JD;Clark CA
自闭症谱系障碍（ASD）的特征是与杏仁核相关的社会认知功能受损。杏仁核的亚区已经被鉴定，它们显示出结构、连接和功能的特异性。对ASD患者杏仁核的连接知之甚少。本研究的目的是调查杏仁核皮质连接的微观结构特性及其与ASD行为的关联，以及特定杏仁核亚区的连接是否与特定的ASD特征相关。使用MRI扫描了51名高功能年轻人（25名ASD患者; 26名对照）的大脑。测量杏仁核体积，并使用概率纤维束成像估计杏仁核皮质连接。一个迭代的“赢家通吃”算法被用来包裹杏仁核的基础上，其主要的皮质连接。杏仁核连通性的测量与临床评分相关。与对照组相比，ASD患者的杏仁核体积更大（F（1，94）= 4.19; p = 0.04）。在连接右侧杏仁核和右侧皮质的白色物质（WM）束中，ASD受试者的平均扩散率增加（t = 2.35; p = 0.05），这与情绪识别缺陷的严重程度相关（rho =-0.53; p = 0.01）。在杏仁核包裹后，ASD受试者连接左侧杏仁核和颞叶皮层的WM各向异性分数降低与更大的注意力转换障碍相关（rho =-0.61; p = 0.02）。这项研究表明，杏仁核体积和杏仁核和皮质之间的连接的微观结构在ASD中改变。研究结果表明，右杏仁核WM束的微观结构与整体ASD的严重程度，但杏仁核亚区域的调查可以确定更具体的协会。
Autism spectrum disorder (ASD) is characterized by impairments in social cognition, a function associated with the amygdala. Subdivisions of the amygdala have been identified which show specificity of structure, connectivity, and function. Little is known about amygdala connectivity in ASD. The aim of this study was to investigate the microstructural properties of amygdala—cortical connections and their association with ASD behaviours, and whether connectivity of specific amygdala subregions is associated with particular ASD traits. The brains of 51 high‐functioning young adults (25 with ASD; 26 controls) were scanned using MRI. Amygdala volume was measured, and amygdala—cortical connectivity estimated using probabilistic tractography. An iterative ‘winner takes all’ algorithm was used to parcellate the amygdala based on its primary cortical connections. Measures of amygdala connectivity were correlated with clinical scores. In comparison with controls, amygdala volume was greater in ASD (F(1,94) = 4.19; p = .04). In white matter (WM) tracts connecting the right amygdala to the right cortex, ASD subjects showed increased mean diffusivity (t = 2.35; p = .05), which correlated with the severity of emotion recognition deficits (rho = −0.53; p = .01). Following amygdala parcellation, in ASD subjects reduced fractional anisotropy in WM connecting the left amygdala to the temporal cortex was associated with with greater attention switching impairment (rho = −0.61; p = .02). This study demonstrates that both amygdala volume and the microstructure of connections between the amygdala and the cortex are altered in ASD. Findings indicate that the microstructure of right amygdala WM tracts are associated with overall ASD severity, but that investigation of amygdala subregions can identify more specific associations.
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影响因子：
2.6
作者：
Dziobek, Isabel;Fleck, Stefan;Convit, Antonio
通讯作者：
Convit, Antonio
DOI：
10.1111/j.1469-7610.2009.02086.x
发表时间：
2009-09-01
影响因子：
7.6
作者：
Cheung, C.;Chua, S. E.;McAlonan, G. M.
通讯作者：
McAlonan, G. M.
影响因子：
5.7
作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
通讯作者：
Lin, Ching-Po
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
DOI：
10.1017/s1355617708081381
发表时间：
2008-11
期刊：
Journal of the International Neuropsychological Society : JINS
影响因子：
--
作者：
Conturo TE;Williams DL;Smith CD;Gultepe E;Akbudak E;Minshew NJ
通讯作者：
Minshew NJ