Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer.
Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer.
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DOI：
10.1038/bjc.2011.569
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发表时间：
2012-01-17
影响因子：
8.8
通讯作者：
Edwards, J.
中科院分区：
文献类型：
--
作者：
Mohammed, Z. M. A.;McMillan, D. C.;Elsberger, B.;Going, J. J.;Orange, C.;Mallon, E.;Doughty, J. C.;Edwards, J.
Ki-67蛋白的免疫组织化学被广泛用于评估肿瘤的增殖，是乳腺癌的一个公认的预后因素。人们有兴趣自动评估Ki-67标签指数(LI)，在处理增加的工作量方面可能会有好处，并提高准确度和精确度。对原发可手术的浸润性导管癌患者进行了Ki-67LI的目视和自动化评估，并对患者的生存率进行了检测。组织芯片(n=379例)Ki-67免疫组化染色采用Slidesath组织免疫分析系统进行可视化自动评分。目视和自动Ki-67LI的一致性很好(ICCC=0.96P<；0.001)。在单变量分析中，视觉(P<；0.001)和自动Ki67LI(P<；0.05)与浸润性导管癌患者以及接受内分泌治疗(三苯氧胺)的患者的癌症特异性生存相关(P<；0.01和P<；0.05自动评分)。Ki-67 LI的自动评估似乎与视觉Ki-67 LI类似。然而，自动Ki-67LI评估在预测乳腺癌患者(包括接受三苯氧胺治疗的患者)的癌症存活率方面效果较差。
Immunohistochemistry of Ki-67 protein is widely used to assess tumour proliferation, and is an established prognostic factor in breast cancer. There is interest in automating the assessment of Ki-67 labelling index (LI) with possible benefits in handling increased workload, with improved accuracy and precision. Visual and automated assessment of Ki-67 LI and survival were examined in patients with primary operable invasive ductal breast cancer. Tissue microarrays (n=379 patients) immunostained for Ki-67 were scored visually and automatically with the Slidepath Tissue IA system. Visual and automated Ki-67 LI were in excellent agreement (ICCC=0.96, P<0.001). On univariate analysis, visual (P<0.001) and automated Ki67 LI (P<0.05) were associated with cancer-specific survival in patients with invasive ductal breast cancer overall and in patients who received endocrine therapy (Tamoxifen) (P<0.01 for visual and P<0.05 for automated scoring). Automated assessment of Ki-67 LI would appear to be comparable to visual Ki-67 LI. However, automated Ki-67 LI assessment was inferior in predicting cancer survival in patients with breast cancer, including patients who received Tamoxifen.
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影响因子：
6.4
作者：
Faratian, Dana;Kay, Charlene;Bartlett, John M. S.
通讯作者：
Bartlett, John M. S.
影响因子：
3.7
作者：
Jung, So-Youn;Han, Wonshik;Noh, Dong-Young
通讯作者：
Noh, Dong-Young
DOI：
10.1186/bcr2434
发表时间：
2009
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dowsett M;A'Hern R;Salter J;Zabaglo L;Smith IE
通讯作者：
Smith IE
全身性炎症反应，肿瘤增殖活性，T淋巴细胞和巨噬细胞浸润，微血管密度和生存率之间的关系之间的关系之间的关系是原发性可手术乳腺癌的患者之间的关系。
影响因子：
8.8
作者：
Al Murri, A. M.;Hilmy, M.;Bell, J.;Wilson, C.;McNicol, A-M;Lannigan, A.;Doughty, J. C.;McMillan, D. C.
通讯作者：
McMillan, D. C.
影响因子：
2.6
作者：
Fasanella S;Leonardi E;Cantaloni C;Eccher C;Bazzanella I;Aldovini D;Bragantini E;Morelli L;Cuorvo LV;Ferro A;Gasperetti F;Berlanda G;Dalla Palma P;Barbareschi M
通讯作者：
Barbareschi M