Three-dimensional epithelial morphogenesis in the developing Drosophila egg.
Three-dimensional epithelial morphogenesis in the developing Drosophila egg.
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DOI：
10.1016/j.devcel.2013.01.017
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发表时间：
2013-02-25
影响因子：
11.8
通讯作者：
Shvartsman, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Osterfield, Miriam;Du, XinXin;Schuepbach, Trudi;Wieschaus, Eric;Shvartsman, Stanislav Y.
果蝇物种蛋壳上呼吸附肢的形态发生为研究细胞片如何产生复杂的三维结构提供了一个强大的实验系统。在黑腹果蝇中，两个管状蛋壳附属物中的每一个都来自由两种不同细胞类型组成的原基。利用实时成像和三维图像重建，我们证明了这种二维原基转化为管涉及面外弯曲，随后是一系列空间有序的细胞插入。这些形态变化与肌球蛋白和巴祖卡蛋白在原基中互补分布的出现有关。这些分布表明，沿上皮顶端细胞边缘的二维线张力模式足以产生所观察到的形态学变化。计算模型表明，这一机制可以解释三维形态发生过程中观察到的组织变形和细胞重排的主要特征。
Morphogenesis of the respiratory appendages on eggshells of Drosophila species provides a powerful experimental system for studying how cell sheets give rise to complex three-dimensional structures. In Drosophila melanogaster, each of the two tubular eggshell appendages is derived from a primordium comprising two distinct cell types. Using live imaging and three-dimensional image reconstruction, we demonstrate that the transformation of this two-dimensional primordium into a tube involves out-of-plane bending followed by a sequence of spatially ordered cell intercalations. These morphological transformations correlate with the appearance of complementary distributions of myosin and Bazooka in the primordium. These distributions suggest that a two-dimensional pattern of line tensions along cell-cell edges on the apical side of the epithelium is sufficient to produce the observed changes in morphology. Computational modeling shows that this mechanism could explain the main features of tissue deformation and cell rearrangements observed during three-dimensional morphogenesis.
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影响因子：
2.5
作者：
Dinkins, Michael B.;Fratto, Victoria M.;LeMosy, Ellen K.
通讯作者：
LeMosy, Ellen K.
影响因子：
2.7
作者：
FRISTROM, D
通讯作者：
FRISTROM, D
影响因子：
9.2
作者：
Landsberg, Katharina P.;Farhadifar, Reza;Dahmann, Christian
通讯作者：
Dahmann, Christian
影响因子：
4.6
作者：
Laplante, Caroline;Nilson, Laura A.
通讯作者：
Nilson, Laura A.
DOI：
10.1242/dev.071407
发表时间：
2012-01
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Kwan KM;Otsuna H;Kidokoro H;Carney KR;Saijoh Y;Chien CB
通讯作者：
Chien CB