Age Dependence of Antimicrobial Resistance Among Fecal Bacteria in Animals: A Scoping Review.
Age Dependence of Antimicrobial Resistance Among Fecal Bacteria in Animals: A Scoping Review.
复制标题
DOI：
10.3389/fvets.2020.622495
复制
发表时间：
2020
影响因子：
3.2
通讯作者：
Volkova VV
中科院分区：
文献类型：
--
作者：
Gaire TN;Scott HM;Sellers L;Nagaraja TG;Volkova VV
简介：随着食用动物年龄的增长，粪便细菌的抗菌素耐药性（AMR）下降的现象已在多个领域的研究中发现。我们进行了一项范围审查，以总结研究活动的程度、范围和性质以及以下问题的数据：“随着动物年龄的增长，肠道/粪便细菌中的AMR是否会发生可预测的变化？"。方法：本综述遵循范围界定综述方法框架。在两个在线数据库（即PubMed®和Web of Science™ Core Collection）中使用关键词检索检索截至2018年11月发表的所有动物（人类除外）的相关文献，不过滤出版日期、地理位置或语言。从纳入的研究中提取数据，进行总结和绘图。研究质量也使用推荐、评估、发展和评价等级（GRADE）指南对所有纳入的论文进行评估。结果：识别出具有食用动物、家禽和犬详细相关数据的出版物（n = 62）。这些研究包括纵向研究（n = 32），在一个食用动物生产系统或小动物集水区的不同年龄组的横断面研究（n = 16），和实验或饮食试验（n = 14）。从20世纪70年代到2018年，在不同地理位置的近三分之二（65%）的研究中，报告了生产牛肉，奶牛和猪粪便细菌中AMR的宿主水平患病率和/或宿主内丰度的下降。在家禽（肉鸡、蛋鸡和成年火鸡）和狗中报告了混合结果，粪便细菌中AMR丰度随年龄增加或减少。结论：数据的定量综合表明，在牛和猪中观察到年龄依赖性AMR现象，与地理位置和特定生产实践无关。目前尚不清楚这种现象是否早于抗菌药物的使用或与抗菌药物的使用有关。然而，近50%的研究早于美国和其他地方食品动物抗菌药物使用政策和法规的最新变化。
Introduction: A phenomenon of decreasing antimicrobial resistance (AMR) among fecal bacteria as food animals age has been noted in multiple field studies. We conducted a scoping review to summarize the extent, range, and nature of research activity and the data for the following question: “does AMR among enteric/fecal bacteria predictably shift as animals get older?”. Methods: This review followed a scoping review methodology framework. Pertinent literature published up until November 2018 for all animals (except humans) was retrieved using keyword searches in two online databases, namely, PubMed® and the Web of Science™ Core Collection, without filtering publication date, geographic location, or language. Data were extracted from the included studies, summarized, and plotted. Study quality was also assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) guidelines for all included papers. Results: The publications with detailed relevant data (n = 62) in food animals, poultry, and dogs were identified. These included longitudinal studies (n = 32), cross-sectional studies of different age groups within one food animal production system or small-animal catchment area (n = 16), and experimental or diet trials (n = 14). A decline in host-level prevalence and/or within-host abundance of AMR among fecal bacteria in production beef, dairy cattle, and swine was reported in nearly two-thirds (65%) of the identified studies in different geographic locations from the 1970's to 2018. Mixed results, with AMR abundance among fecal bacteria either increasing or decreasing with age, have been reported in poultry (broiler chicken, layer, and grow-out turkey) and dogs. Conclusions: Quantitative synthesis of the data suggests that the age-dependent AMR phenomenon in cattle and swine is observed irrespective of geographic location and specific production practices. It is unclear whether the phenomenon predates or is related to antimicrobial drug use. However, almost 50% of the identified studies predate recent changes in antimicrobial drug use policy and regulations in food animals in the United States and elsewhere.
登录
查看更多内容
影响因子：
3.2
作者：
Lhermie, Guillaume;Chiu, Leslie Verteramo;Grohn, Yrjo Tapio
通讯作者：
Grohn, Yrjo Tapio
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
2.5
作者：
Aarestrup, Frank M.;Duran, C. Oliver;Burch, David G. S.
通讯作者：
Burch, David G. S.
影响因子：
2.4
作者：
Greig, J.;Rajic, A.;LeJeune, J.
通讯作者：
LeJeune, J.
影响因子：
4.4
作者：
Hoyle, DV;Shaw, DJ;Woolhouse, MEJ
通讯作者：
Woolhouse, MEJ