Gut microbiome-host interactions in health and disease.
Gut microbiome-host interactions in health and disease.
复制标题
DOI：
10.1186/gm228
复制
发表时间：
2011-03-04
期刊：
影响因子：
12.3
通讯作者：
Nicholson JK
中科院分区：
文献类型：
--
作者：
Kinross JM;Darzi AW;Nicholson JK
肠道微生物组是描述人类胃肠道系统中大量共生微生物及其集体相互作用基因组的术语。最近的研究表明，肠道微生物组为宿主执行许多重要的生化功能，并且微生物组的紊乱与许多不同的人类疾病过程相关。基于下一代“组学”技术的系统生物学方法现在能够在详细的遗传和功能（转录组学，蛋白质组学和代谢）水平上描述肠道微生物组，为肠道微生物组在人类健康中的重要性提供新的见解，并且它们能够绘制物种，个体和群体之间的微生物组变异性。这已经确立了肠道微生物组在许多全身性疾病状态（如肥胖和心血管疾病）和肠道病症（如炎症性肠病）的疾病发病机制中的重要性。因此，了解微生物组活性对于未来个性化医疗保健策略的发展至关重要，并可能为药物开发提供新的靶点。在这里，我们回顾了最近的宏基因组学和代谢组学方法，这些方法使我们能够在理解与人类健康相关的肠道微生物组活性以及肠道微生物调节治疗疾病方面取得进展。我们还描述了在这个快速增长的领域，未来的个性化医疗保健策略的研究可能的途径。
The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective interacting genomes. Recent studies have suggested that the gut microbiome performs numerous important biochemical functions for the host, and disorders of the microbiome are associated with many and diverse human disease processes. Systems biology approaches based on next generation 'omics' technologies are now able to describe the gut microbiome at a detailed genetic and functional (transcriptomic, proteomic and metabolic) level, providing new insights into the importance of the gut microbiome in human health, and they are able to map microbiome variability between species, individuals and populations. This has established the importance of the gut microbiome in the disease pathogenesis for numerous systemic disease states, such as obesity and cardiovascular disease, and in intestinal conditions, such as inflammatory bowel disease. Thus, understanding microbiome activity is essential to the development of future personalized strategies of healthcare, as well as potentially providing new targets for drug development. Here, we review recent metagenomic and metabonomic approaches that have enabled advances in understanding gut microbiome activity in relation to human health, and gut microbial modulation for the treatment of disease. We also describe possible avenues of research in this rapidly growing field with respect to future personalized healthcare strategies.
登录
查看更多内容
影响因子：
4.7
作者：
Hambly, RJ;Rumney, CJ;Rowland, IR
通讯作者：
Rowland, IR
影响因子：
4.7
作者：
Finegold, Sydney M.
通讯作者：
Finegold, Sydney M.
影响因子：
--
作者：
Aura, Anna-Marja;Mattila, Ismo;Oksman-Caldentey, Kirsi-Marja
通讯作者：
Oksman-Caldentey, Kirsi-Marja
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
3.6
作者：
Girard, Stephanie-Anne;Bah, Thierno Madjou;Rousseau, Guy
通讯作者：
Rousseau, Guy