A practical guide to the oral microbiome and its relation to health and disease.
A practical guide to the oral microbiome and its relation to health and disease.
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DOI：
10.1111/odi.12509
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发表时间：
2017-04
期刊：
影响因子：
3.8
通讯作者：
Paster BJ
中科院分区：
文献类型：
--
作者：
Krishnan K;Chen T;Paster BJ
口腔微生物群非常复杂，平均成年人口腔中含有约 50 至 1000 亿个细菌，代表约 200 种主要细菌种类。总共有大约 700 个主要类群，其中不到 1/3 尚未在体外生长。与其他身体部位相比，口腔微生物组是独特且易于获取的。有大量文献描述口腔微生物组并讨论细菌在口腔健康和疾病中可能发挥的作用。然而，这篇综述的目的不是重复这些详细的研究，而是教育读者了解口腔微生物组的本质，即存在数量和类型丰富的细菌，有快速确定细菌关联的分子方法，宿主定植具有位点特异性，与口腔健康和疾病存在特定关联，口腔细菌可以作为非口腔疾病的生物标志物，口腔微生物谱可能具有评估疾病风险的潜在用途。
The oral microbiome is incredibly complex with the average adult harboring about 50 to 100 billion bacteria in the oral cavity, which represent about 200 predominant bacterial species. Collectively, there are approximately 700 predominant taxa of which less than 1/3 still have not yet been grown in vitro. Compared to other body sites, the oral microbiome is unique and readily accessible. There is extensive literature available describing the oral microbiome and discussing the roles that bacteria may play in oral health and disease. However, the purpose of this review is not to rehash these detailed studies but rather to educate the reader with understanding the essence of the oral microbiome, namely that there are abundant bacteria in numbers and types, that there are molecular methods to rapidly determine bacterial associations, that there is site-specificity for colonization of the host, that there are specific associations with oral health and disease, that oral bacteria may serve as biomarkers for non-oral diseases, and that oral microbial profiles may have potential use to assess disease risk.
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作者：
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