Multi-electrode stimulation in somatosensory cortex increases probability of detection.
Multi-electrode stimulation in somatosensory cortex increases probability of detection.
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DOI：
10.1088/1741-2560/10/5/056013
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发表时间：
2013-10
影响因子：
4
通讯作者：
Miller LE
中科院分区：
文献类型：
--
作者：
Zaaimi B;Ruiz-Torres R;Solla SA;Miller LE
在过去的十年里，解码来自运动皮层的控制信号的脑机接口（BMI）得到了巨大的发展，但几乎所有的脑机接口都完全依赖于视觉来提供反馈。现在，人们越来越有兴趣开发一种传入接口来取代自然的躯体感觉，就像耳蜗植入物对听觉所做的那样。对体感神经假体的初步实验主要针对触觉，但本体感觉，即肢体位置和运动的感觉，对于运动控制也至关重要。然而，皮质的本体感受区缺乏触觉区的精确躯体定位。我们之前已经证明，2区的相邻神经元只有微弱的倾向，发出类似方向的手部运动信号。因此，在许多研究中使用的相对较大的电流刺激可能会激活一组相当异质的神经元。在这里，我们比较了在亚阈值水平下单电极刺激的效果与组合刺激多达七个电极的效果。我们发现，与单个电极相比，成对电极对刺激的灵敏度（d′）平均增加了0.17（大约增加了30%），而七个电极的组增加了2.5（260%）。我们认为，由几百个电极组成的本体感受界面可能比使用更少电极和更大电流的BMI产生更安全，更有效的感觉。
Brain machine interfaces (BMIs) that decode control signals from motor cortex have developed tremendously in the past decade, but virtually all rely exclusively on vision to provide feedback. There is now increasing interest in developing an afferent interface to replace natural somatosensation, much as the cochlear implant has done for the sense of hearing. Preliminary experiments toward a somatosensory neuroprosthesis have mostly addressed the sense of touch, but proprioception, the sense of limb position and movement, is also critical for the control of movement. However, proprioceptive areas of cortex lack the precise somatotopy of tactile areas. We showed previously that there is only a weak tendency for neighboring neurons in area 2 to signal similar directions of hand movement. Consequently, stimulation with the relatively large currents used in many studies is likely to activate a rather heterogeneous set of neurons. Here, we have compared the effect of single-electrode stimulation at sub-threshold levels to the effect of stimulating as many as seven electrodes in combination. We found a mean enhancement in the sensitivity to the stimulus (d′) of 0.17 for pairs compared to individual electrodes (an increase of roughly 30%), and an increase of 2.5 for groups of seven electrodes (260%). We propose that a proprioceptive interface made up of several hundred electrodes may yield safer, more effective sensation than a BMI using fewer electrodes and larger currents.
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影响因子：
3
作者：
Negi S;Bhandari R;Rieth L;Van Wagenen R;Solzbacher F
通讯作者：
Solzbacher F
影响因子：
4
作者：
McCreery D;Pikov V;Troyk PR
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Troyk PR
影响因子：
14.5
作者：
Schmidt, EM;Bak, MJ;Vallabhanath, P
通讯作者：
Vallabhanath, P
影响因子：
3
作者：
Nowak, LG;Bullier, J
通讯作者：
Bullier, J
影响因子：
3.5
作者：
O'Doherty, Joseph E.;Lebedev, Mikhail A.;Nicolelis, Miguel A. L.
通讯作者：
Nicolelis, Miguel A. L.