Neural electrode degradation from continuous electrical stimulation: comparison of sputtered and activated iridium oxide.
Neural electrode degradation from continuous electrical stimulation: comparison of sputtered and activated iridium oxide.
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DOI：
10.1016/j.jneumeth.2009.10.016
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发表时间：
2010-01-30
影响因子：
3
通讯作者：
Solzbacher F
中科院分区：
文献类型：
--
作者：
Negi S;Bhandari R;Rieth L;Van Wagenen R;Solzbacher F
神经电极在生理液体中的性能，特别是在长期使用中，对于功能性电刺激装置的成功至关重要。犹他州电极阵列（UEA）的尖端涂有溅射氧化铱膜（SIROF）和活化氧化铱膜（AIROF），以研究与功能性电刺激（FES）一致的电荷注入期间的降解。阵列在50 Hz的频率下经受连续的双相、阴极优先、电荷平衡（具有相等的阴极和阳极脉冲宽度）电流脉冲7小时（> 1百万个脉冲）。改变电流脉冲的幅度和宽度以确定涂层的损伤阈值。采用扫描电子显微镜、电感耦合等离子体质谱、电化学阻抗谱和循环伏安法对降解过程进行了表征。发现注入电荷和每相电荷密度在破坏电极中起协同作用。UEA的SIROF涂覆的电极尖端的损伤阈值在60 nC（每相1.9 mC/cm 2的电荷密度）和80 nC（每相1.0 mC/cm 2的电荷密度）之间。而对于AIROF涂覆的电极头，阈值在每相0.9 mC/cm 2的电荷密度的40 nC和每相0.5 mC/cm 2的电荷密度的50 nC之间。与AIROF相比，SIROF显示出更高的损伤阈值，因此强烈推荐用作刺激材料。
The performance of neural electrodes in physiological fluid, especially in chronic use, is critical for the success of functional electrical stimulation devices. Tips of the Utah Electrode Arrays (UEA) were coated with sputtered iridium oxide film (SIROF) and activated iridium oxide film (AIROF) to study the degradation during charge injection consistent with functional electrical stimulation (FES). The arrays were subjected to continuous biphasic, cathodal first, charge balanced (with equal cathodal and anodal pulse widths) current pulses for 7 hours (> 1 million pulses) at a frequency of 50 Hz. The amplitude and width of the current pulses were varied to determine the damage threshold of the coatings. Degradation was characterized by scanning electron microscopy, inductively coupled plasma mass spectrometry, electrochemical impedance spectroscopy and cyclic voltammetry. The injected charge and charge density per phase were found to play synergistic role in damaging the electrodes. The damage threshold for SIROF coated electrode tips of the UEA was between 60 nC with a charge density of 1.9 mC/cm2 per phase and 80 nC with a charge density of 1.0 mC/cm2 per phase. While for AIROF coated electrode tips, the threshold was between 40 nC with a charge density of 0.9 mC/cm2 per phase, and 50 nC with a charge density of 0.5 mC/cm2 per phase. Compared to AIROF, SIROF showed higher damage threshold and therefore is highly recommended to be used as a stimulation material.
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DOI：
10.1002/jbm.b.31223
发表时间：
2009-05
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Cogan SF;Ehrlich J;Plante TD;Smirnov A;Shire DB;Gingerich M;Rizzo JF
通讯作者：
Rizzo JF
影响因子：
5.3
作者：
AGNEW, WF;YUEN, TGH;BULLARA, LA
通讯作者：
BULLARA, LA
影响因子：
4.6
作者：
Weiland, JD;Anderson, DJ
通讯作者：
Anderson, DJ
影响因子：
4.1
作者：
MORTIMER, JT;SHEALY, CN;WHEELER, C
通讯作者：
WHEELER, C
影响因子：
8.4
作者：
Negi, S.;Bhandari, R.;Solzbacher, F.
通讯作者：
Solzbacher, F.