Huaier extract exerts immunomodulatory effects by regulating serum cytokines in breast cancer
Huaier extract exerts immunomodulatory effects by regulating serum cytokines in breast cancer
复制标题
槐耳提取物通过调节乳腺癌血清细胞因子发挥免疫调节作用
DOI：
10.21037/22831
复制
发表时间：
2018-07
影响因子：
0.9
通讯作者：
Yang Qifeng
中科院分区：
文献类型：
--
作者：
Zhang Li;Zhang Ning;Qu Xinyu;Li Yaming;Yang Qifeng
背景资料：怀尔提取物是一种具有1,600年历史的传统中药（TCM），最近已成为中国的辅助抗癌药物。已有研究表明槐耳提取物具有多种抗癌作用。然而，槐耳提取物是否对乳腺癌患者血清细胞因子谱具有免疫调节作用仍不清楚。研究方法：收集齐鲁医院19例乳腺癌患者术前服用槐耳提取物的血清标本38份，采用Bio-ProTM细胞因子测定法检测血清细胞因子水平。建立小鼠乳腺癌模型，进一步验证槐耳提取物的免疫调节作用，采用酶联免疫吸附试验（ELISA）检测血清细胞因子水平，并计数肺转移。
结果如下：本研究发现槐耳提取物能显著降低乳腺癌患者血清MCP-1、MIP-1β水平（P < 0. 05）。结论：本研究结果表明槐耳提取物能调节乳腺癌患者血清细胞因子水平，减少肺转移结节数。我们的研究还确定了血清细胞因子谱，这可能会预测疾病的结果，并用于监测槐耳提取物治疗乳腺癌的疗效。
Background: Huaier extract, a traditional Chinese medicine (TCM) with a 1,600-year history, has recently become a complementary anticancer drug in China. Previous studies have demonstrated that Huaier extract has multiple anticancer effects. However, whether Huaier extract has immunomodulatory effects on serum cytokine profiles in breast cancer patients remains unknown. Methods: Thirty-eight serum specimens were collected from 19 female breast cancer patients who were treated with Huaier extract before surgery in Qilu Hospital, and serum cytokines were analyzed by Bio-Plex ProTM cytokine assays. Murine breast cancer model was built to further verify the immunomodulatory effects of Huaier extract, and serum cytokine levels were detected by enzyme linked immunosorbent assay (ELISA) assay and pulmonary metastasis were counted.
Results: In this study, we found that Huaier extract significantly decreased the MCP-1, MIP-1β levels (P Conclusions: The results of this study showed that Huaier extract regulated serum cytokines levels and decreased the number of metastatic lung nodules in breast cancer. Our study also identified a serum cytokine profile, which potentially could predict disease outcome and be used to monitor the efficacy of Huaier extract treatment in breast cancer.
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DOI：
--
发表时间：
2011
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
--
作者：
Xiao Xu;Q. Wei;Kai Wang;Q. Ling;Haiyang Xie;Lin Zhou;Shusen Zheng
通讯作者：
Xiao Xu;Q. Wei;Kai Wang;Q. Ling;Haiyang Xie;Lin Zhou;Shusen Zheng
影响因子：
4.6
作者：
Whiteside TL
通讯作者：
Whiteside TL
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
L. Ries;D. Harkins;Martin Krapcho;A. Mariotto;B. Miller;E. Feuer;L. Clegg;M. Eisner;Marie-Josèphe H
通讯作者：
L. Ries;D. Harkins;Martin Krapcho;A. Mariotto;B. Miller;E. Feuer;L. Clegg;M. Eisner;Marie-Josèphe H
影响因子：
7.2
作者：
Baghel, Khemraj Singh;Tewari, Brij Nath;Bhadauria, Smrati
通讯作者：
Bhadauria, Smrati
DOI：
10.1016/j.biocel.2003.10.019
发表时间：
2004-10-01
影响因子：
4
作者：
Maurer, M;von Stebut, E
通讯作者：
von Stebut, E