Iron supplementation of breastfed infants from an early age.
Iron supplementation of breastfed infants from an early age.
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DOI：
10.3945/ajcn.2008.26591
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发表时间：
2009-02
影响因子：
7.1
通讯作者：
Jeter, Janice M.
中科院分区：
文献类型：
--
作者：
Ziegler, Ekhard E.;Nelson, Steven E.;Jeter, Janice M.
在母乳喂养的婴儿中，6个月前缺铁的情况虽然不常见，但在工业化国家是常见的。从小开始补充铁可以预防缺铁。这项研究评估了母乳喂养婴儿早期补充铁的效果，并检验了补充铁可以改善铁状态的假设。监测潜在的不良反应(耐受性、生长)。这项前瞻性的安慰剂对照研究包括纯母乳喂养的婴儿，他们在1个月大的时候被随机分配到铁(N=37)或安慰剂(N=38)。铁(7 mg/d，含硫酸亚铁复合维生素制剂)或安慰剂(不含铁的复合维生素制剂)在1~5.5mo龄期间服用。4个月后允许补充食物。婴儿被跟踪到18个月大。每两个月测定一次血中铁蛋白、转铁蛋白受体和血红蛋白浓度以及红细胞指数。记录大便的稠度、颜色和进食行为。在干预4个月和5.5个月时，补充铁引起铁状态的轻度增加，但在此之后并不明显。铁补充剂耐受性良好，对生长没有可测量的影响。1名婴儿在5.5个月时患上缺铁性贫血。随着时间的推移追踪血浆铁蛋白和血红蛋白。母乳喂养的婴儿早期补充铁是可行的，并且可以短暂地提高铁状态，但不会增加血液状态。铁是大多数婴儿都能忍受的。缺铁性贫血的患病率在未补充母乳喂养的婴儿中较低(3%)，在生命的前6个月。
In breastfed infants, iron deficiency before 6 mo of life, although uncommon, is observed in industrialized countries. Iron supplementation starting at an early age may prevent iron deficiency. The study assessed the effect of early iron supplementation of breastfed infants and tested the hypothesis that iron supplementation enhances iron status. Potential adverse effects (tolerance, growth) were monitored. The prospective, placebo-controlled study involved exclusively breastfed infants who were randomly assigned at 1 mo of age to iron (N=37) or placebo (N=38). Iron (7 mg/d as multivitamin preparation with ferrous sulfate) or Placebo (multivitamin preparation without iron) were given from 1 to 5.5 mo of age. Complementary foods were allowed after 4 mo. Infants were followed to 18 mo of age. Blood concentrations of ferritin, transferrin receptor and hemoglobin as well as red cell indices were determined at bi-monthly intervals. Stool consistency and color and feeding behavior were recorded. Fe supplementation caused modest augmentation of iron status during the intervention at 4 and 5.5 mo but not thereafter. Iron supplements were well tolerated and had no measurable effect on growth. One infant developed iron deficiency anemia by 5.5 mo of age. Plasma ferritin and hemoglobin tracked over time. Early iron supplementation of breastfed infants is feasible and transiently increases iron status but not hematologic status. Iron is tolerated by most infants. The prevalence of iron deficiency anemia is low (3%) among unsupplemented breastfed infants in the first 6 mo of life.
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影响因子：
5.1
作者：
Friel, JK;Aziz, K;Adams, RJ
通讯作者：
Adams, RJ
影响因子：
7.1
作者：
Beard, John L.;Murray-Kolb, Laura E.;Angelilli, Mary Lu
通讯作者：
Angelilli, Mary Lu
影响因子：
5.1
作者：
Domellöf, M;Cohen, RJ;Lönnerdal, B
通讯作者：
Lönnerdal, B
影响因子：
3.6
作者：
FOMON, SJ;ZIEGLER, EE;FRANTZ, JA
通讯作者：
FRANTZ, JA
影响因子：
5.1
作者：
Georgieff, MK;Wewerka, SW;deRegnier, RA
通讯作者：
deRegnier, RA