H2DB: a heritability database across multiple species by annotating trait-associated genomic loci.
H2DB: a heritability database across multiple species by annotating trait-associated genomic loci.
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DOI：
10.1093/nar/gks1216
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
Nakamura Y
中科院分区：
文献类型：
--
作者：
Kaminuma E;Fujisawa T;Tanizawa Y;Sakamoto N;Kurata N;Shimizu T;Nakamura Y
H2 DB（http：//tga.nig.ac.jp/h2db/）是人类和其他物种遗传力估计的注释数据库，已被开发为连接性状相关基因组位点的知识数据库。遗传力估计已被调查的个别物种，特别是在人类双胞胎研究和植物/动物育种研究。然而，似乎没有人类和其他物种的综合遗传力数据库。在这里，我们介绍了一个注释数据库的各种物种的遗传遗传性，人工策划在线公共资源的PUBMED摘要和期刊目录进行注释。建议的遗传力数据库包含属性信息的性状描述，实验条件，性状相关的基因组位点和广义和狭义遗传力规格。注释的性状相关基因组位点，其中大部分是来自全基因组关联研究的单核苷酸多态性，可能是实验科学家的宝贵资源。此外，为了讨论基于表型分类的遗传力分布，我们将表型本体分配给注释的性状。
H2DB (http://tga.nig.ac.jp/h2db/), an annotation database of genetic heritability estimates for humans and other species, has been developed as a knowledge database to connect trait-associated genomic loci. Heritability estimates have been investigated for individual species, particularly in human twin studies and plant/animal breeding studies. However, there appears to be no comprehensive heritability database for both humans and other species. Here, we introduce an annotation database for genetic heritabilities of various species that was annotated by manually curating online public resources in PUBMED abstracts and journal contents. The proposed heritability database contains attribute information for trait descriptions, experimental conditions, trait-associated genomic loci and broad- and narrow-sense heritability specifications. Annotated trait-associated genomic loci, for which most are single-nucleotide polymorphisms derived from genome-wide association studies, may be valuable resources for experimental scientists. In addition, we assigned phenotype ontologies to the annotated traits for the purposes of discussing heritability distributions based on phenotypic classifications.
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影响因子：
14.9
作者：
Hu, Zhi-Liang;Fritz, Eric Ryan;Reecy, James M
通讯作者：
Reecy, James M
影响因子：
14.9
作者：
Cariaso M;Lennon G
通讯作者：
Lennon G
影响因子：
12.3
作者：
Mungall CJ;Gkoutos GV;Smith CL;Haendel MA;Lewis SE;Ashburner M
通讯作者：
Ashburner M
影响因子：
3.8
作者：
MOUSSEAU, TA;ROFF, DA
通讯作者：
ROFF, DA
DOI：
10.1073/pnas.0903103106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Hindorff, Lucia A.;Sethupathy, Praveen;Manolio, Teri A.
通讯作者：
Manolio, Teri A.