Nonprogressive and progressive primate immunodeficiency lentivirus infections.
Nonprogressive and progressive primate immunodeficiency lentivirus infections.
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DOI：
10.1016/j.immuni.2010.06.004
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发表时间：
2010-06-25
期刊：
影响因子：
32.4
通讯作者：
Douek DC
中科院分区：
文献类型：
--
作者：
Brenchley JM;Silvestri G;Douek DC
猴免疫缺陷病毒(SIV)的自然宿主可以而且通常是自然感染物种特有的SIV，但不会发展为获得性免疫缺陷综合症(AIDS)。这些自然宿主保持高SIV病毒载量，但避免免疫缺陷。阐明自然宿主与SIV共存而不显性疾病的机制可能为了解艾滋病的发病机制提供重要信息。在过去的几年里，在主要在烟灰猴(Sms)、非洲绿猴(AGM)和沙棘上进行的研究中描述了自然SIV感染的几个关键特征。自然的SIV宿主能够避免与HIV感染者的疾病进展相关的慢性、全身性免疫系统激活，并已知下调SIV受体的表达。从这个角度来看，我们认为区分非进行性和进行性HIV或SIV感染的一个关键因素是在感染和杀死CD4+T细胞的病毒面前维持T细胞免疫能力，阐明在自然SIV感染急性期期间和之后潜在的免疫功能保持的机制可能会导致设计新的预防和治疗措施来治疗慢性HIV感染。
Natural hosts for simian immunodeficiency virus (SIV)can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to co-exist with SIV without overt disease may provide crucial information for understanding AIDS pathogenesis. Over the past few years, several key features of natural SIV infections have been described in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and mandrills. Natural SIV hosts are able to avoid the chronic, generalized immune system activation that is associated with disease progression in HIV-infected individuals and are known to down-modulate the expression of the receptors for SIV. In this perspective we propose that a critical factor that differentiates nonprogressive from progressive HIV or SIV infection is the maintenance of T cell immune competence in the face of a virus that infects and kills CD4+ T cells Elucidation of the mechanisms underlying the preservation of immune function during and after the acute phase of natural SIV infection may lead to the design of novel preventive and therapeutic interventions for treatment of chronic HIV infection.
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记忆中的CD4下调CD4+ T细胞体内使非洲绿色猴子具有对进行性Sivagm感染的抗性。
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
8.8
作者：
Baroncelli, Silvia;Galluzzo, Clementina Maria;Palmisano, Lucia
通讯作者：
Palmisano, Lucia
影响因子：
20.3
作者：
Deeks, SG;Kitchen, CMR;Hecht, FM
通讯作者：
Hecht, FM
影响因子：
4.8
作者：
Chen, Y;Thai, P;Wu, R
通讯作者：
Wu, R
影响因子：
8
作者：
Ciccone, E. J.;Read, S. W.;Sereti, I.
通讯作者：
Sereti, I.