Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study.
Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study.
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DOI：
10.1001/jamapsychiatry.2016.2479
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发表时间：
2016-12-01
期刊：
影响因子：
25.8
通讯作者：
Woods SW
中科院分区：
文献类型：
--
作者：
Seidman LJ;Shapiro DI;Stone WS;Woodberry KA;Ronzio A;Cornblatt BA;Addington J;Bearden CE;Cadenhead KS;Cannon TD;Mathalon DH;McGlashan TH;Perkins DO;Tsuang MT;Walker EF;Woods SW
神经认知是精神分裂症和其他精神障碍的中心特征。识别神经认知功能的模式和严重程度，在“近精神病”，前驱，临床高风险（NH3）状态是必要的，以开发准确的精神病预测和更有效的和潜在的预防性治疗。识别与精神分裂相关联的核心神经认知功能障碍，并测量神经认知测试预测向精神病转变的能力。确定神经认知缺陷是否可靠或由潜在混杂因素解释。病例对照研究。在北美前驱症状纵向研究（NAPLS-2）的第二阶段中收集了2008-2012年的基线神经认知功能。一个由八所大学组成的研究北美精神病前驱症状的门诊项目联盟。健康对照组（HC，n =264），包括137名男性和127名女性HC以及398名男性和291名女性12-35岁的健康个体。一项自然的观察性研究。那些谁没有过渡到精神病，用药和未用药组之间的差异，以及转换的时间之间的神经认知差异。19个神经心理测验和4个因子由因子分析得出。这些因素是执行功能/视觉空间，言语，注意/工作记忆和陈述性记忆。在广泛的轻度至中度损伤中，与HCs相比，HCs在注意力/工作记忆和陈述性记忆方面受到显着损害。与对照组相比，转换者有很大的陈述性记忆和注意力/工作记忆缺陷（Cohen's d = ~0.8，p <.001），并且在这些维度上比非转换者明显更差。在考克斯回归中，除了年龄、部位和阳性精神病症状外，陈述性记忆受损和言语（病前）能力高可显著预测后来转变为精神病的患者的转换时间。损害的模式不能用病前或目前的一般认知能力、药物、目前的抑郁症、酒精或大麻滥用来解释。神经认知障碍是精神病患者的一个显著特征，尤其是那些后来发展为精神病的人。测试挖掘口头和视觉陈述性记忆和注意力/工作记忆是最敏感的精神病之间的那些在CHR。针对增强神经认知功能的干预措施是必要的，在这一人群中。
Neurocognition is a central characteristic of schizophrenia and other psychotic disorders. Identifying the pattern and severity of neurocognitive functioning during the “near-psychotic”, prodromal, clinical high-risk (CHR) state is necessary to develop accurate predictors of psychosis and more effective and potentially preventative treatments. Identify core neurocognitive dysfunctions associated with the CHR phase, and measure the ability of neurocognitive tests to predict the transition to psychosis. Determine if the neurocognitive deficits are robust or explained by potential confounders. Case control study. Baseline neurocognitive functioning collected from 2008–2012 in the second phase of the North American Prodrome Longitudinal Study (NAPLS-2). A consortium of eight university-based, outpatient programs studying the psychosis prodrome in North America. CHR individuals (n=689) and healthy controls (HCs, n=264) consisting of 137 male and 127 female HC and 398 male and 291 female CHR individuals ages 12–35. A naturalistic, observational study. Neurocognitive differences between those who did and did not transition to psychosis, differences between medicated and unmedicated groups, and time to conversion. Nineteen neuropsychological tests and four factors derived from factor analysis. The factors were Executive Function/Visual-Spatial, Verbal, Attention/Working Memory, and Declarative Memory. Amongst widespread mild to moderate impairments, CHR individuals were significantly impaired compared to HCs on Attention/Working Memory and Declarative Memory. CHR converters had large Declarative Memory and Attention/Working Memory deficits (Cohen’s d = ~0.8, p <.001) compared with controls and were significantly worse on these dimensions than non-converters. In Cox regression, impaired Declarative Memory and high Verbal (premorbid) ability in addition to age, site and positive psychotic symptoms, significantly predicted time to conversion in those who later transitioned to psychosis. The pattern of impairments could not be accounted for by premorbid or current general cognitive ability, medications, current depression, alcohol or cannabis abuse. Neurocognitive impairment is a robust characteristic of CHR individuals, especially those who later develop psychosis. Tests tapping verbal and visual declarative memory and attention/working memory were most sensitive to imminent psychosis amongst those at CHR. Interventions targeting the enhancement of neurocognitive functioning are warranted in this population.
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影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
6.6
作者：
Bora, Emre;Murray, Robin M.
通讯作者：
Murray, Robin M.
影响因子：
10.5
作者：
ADDINGTON, D;ADDINGTON, J;MATICKATYNDALE, E
通讯作者：
MATICKATYNDALE, E
影响因子：
17.7
作者：
Brewer, WJ;Wood, SJ;Pantelis, C
通讯作者：
Pantelis, C
DOI：
10.1176/appi.ajp.2013.12101298
发表时间：
2013-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Hill SK;Reilly JL;Keefe RS;Gold JM;Bishop JR;Gershon ES;Tamminga CA;Pearlson GD;Keshavan MS;Sweeney JA
通讯作者：
Sweeney JA