Immunology of Gut-Bone Signaling.

Immunology of Gut-Bone Signaling.
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DOI:
10.1007/978-3-319-66653-2_5
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发表时间:
2017
影响因子:
--
通讯作者:
Parameswaran N
Parameswaran N
中科院分区:
医学4区
文献类型:
--
作者:
Collins FL;Schepper JD;Rios-Arce ND;Steury MD;Kang HJ;Mallin H;Schoenherr D;Camfield G;Chishti S;McCabe LR;Parameswaran N

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近年来,胃肠道和骨骼健康之间的联系开始引起人们的极大关注。肠道微生物群的生态失调与许多与骨质流失有关的疾病的病理有关。此外,益生菌对肠道微生物群的调节已显示出有益的局部和全身效应。在本章中,我们讨论肠道和骨免疫系统,探讨肠道疾病如何影响免疫系统,并检查这些病理变化如何对骨骼健康产生不利影响。
In recent years a link between the gastro-intestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system and examine how these pathologic changes could adversely impact bone health.
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