Combined Algorithm-Based Adaptations of Insulin Dose and Carbohydrate Intake During Exercise in Children With Type 1 Diabetes: Results From the CAR2DIAB Study.
Combined Algorithm-Based Adaptations of Insulin Dose and Carbohydrate Intake During Exercise in Children With Type 1 Diabetes: Results From the CAR2DIAB Study.
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DOI：
10.3389/fendo.2021.658311
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发表时间：
2021
影响因子：
5.2
通讯作者：
Moniotte S
中科院分区：
文献类型：
--
作者：
Lysy PA;Absil H;Gasser E;Boughaleb H;Barrea T;Moniotte S
根据联合算法调整胰岛素剂量和碳水化合物摄入量后，评价1型糖尿病儿童或青少年在两次监测有氧运动期间皮下葡萄糖的变化。12例1型糖尿病患者（15.1 ± 2年;糖尿病病程：9.5 ± 3.1年）在心脏评估后进行了两个系列的运动。第一个系列（TE#1）包括一个中等到剧烈强度的监测运动，加上一轮最大的努力。第二个系列的练习（TE#2）是在真实的生活中进行的，由连接的手表进行分类和监控。根据决策算法调整胰岛素剂量和速效碳水化合物后进行TE#2治疗。患者未发生重度低血糖、症状性高血糖或酮症相关高血糖。TE#2期间CGM数据（15 h）的分析显示血糖平均值[±标准差]总体改善（TE#1期间104 ± 14 mg/dl vs. 122 ± 17 mg/dl; p < 0.001），与进行运动后4 h至15 h期间高血糖比例降低相关。低血糖的比例没有改变，除了在TE#2 + 4 - 8小时期间，观察到低血糖<60 mg/dl显著增加（25% vs. 6.2%; p = 0.04），但没有并发症。在我们的儿科系列研究中，胰岛素剂量和碳水化合物摄入量的算法调整应用在1型糖尿病儿童和青少年进行实时运动后15小时内全面改善了血糖控制。
To evaluate the evolution of subcutaneous glucose during two sessions of monitored aerobic exercise in children or adolescents with type 1 diabetes after adaptation of insulin doses and carbohydrate intake according to a combined algorithm. Twelve patients with type 1 diabetes (15.1 ± 2 years; diabetes duration: 9.5 ± 3.1 years) performed two series of exercise sessions after cardiac evaluation. The first series (TE#1) consisted in a monitored exercise of moderate to vigorous intensity coupled with a bout of maximum effort. The second series of exercises (TE#2) was carried out in real life during exercises categorized and monitored by connected watches. TE#2 sessions were performed after adaptation of insulin doses and fast-acting carbohydrates according to decision algorithms. Patients did not experience episodes of severe hypoglycemia, symptomatic hyperglycemia, or hyperglycemia associated with ketosis. Analysis of CGM data (15 h) during TE#2 sessions revealed an overall improvement in glycemic average [± standard deviation] (104 ± 14 mg/dl vs. 122 ± 17 mg/dl during TE#1; p < 0.001), associated with a decrease in proportion of hyperglycemia in periods ranging from 4 h to 15 h after performing the exercises. The proportion of hypoglycemia was not changed, except during the TE#2 +4–8 h period, where a significant increase in hypoglycemia <60 mg/dl was observed (25% vs. 6.2%; p = 0.04), yet without concurrent complications. In our pediatric series, the application of algorithmic adaptations of insulin doses and carbohydrate intake has globally improved glycemic control during 15 h after real-time exercises performed by children and adolescents with type 1 diabetes.
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影响因子：
2.1
作者：
Brunvand L;Fugelseth D;Stensaeth KH;Dahl-Jørgensen K;Margeirsdottir HD
通讯作者：
Margeirsdottir HD
影响因子：
3.4
作者：
Adolfsson, Peter;Riddell, Michael C.;Hofer, Sabine E.
通讯作者：
Hofer, Sabine E.
影响因子：
1.7
作者：
Roelants, M.;Hauspie, R.;Hoppenbrouwers, K.
通讯作者：
Hoppenbrouwers, K.
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
3.4
作者：
Smart, Carmel E.;Annan, Francesca;Acerini, Carlo L.
通讯作者：
Acerini, Carlo L.