Enhanced adult neurogenesis increases brain stiffness: in vivo magnetic resonance elastography in a mouse model of dopamine depletion.
Enhanced adult neurogenesis increases brain stiffness: in vivo magnetic resonance elastography in a mouse model of dopamine depletion.
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DOI：
10.1371/journal.pone.0092582
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sack I
中科院分区：
文献类型：
--
作者：
Klein C;Hain EG;Braun J;Riek K;Mueller S;Steiner B;Sack I
大脑的机械网络是神经健康的主要贡献者，并已被体内磁共振弹性成像（MRE）认为是对疾病的高度反应。然而，到目前为止，只观察到大脑软化，没有机制知道如何逆转衰老或疾病期间神经弹性的普遍下降。我们在帕金森病（PD）中观察到的1-甲基-4-苯基-1,2,3,6-盐酸四氢吡啶（MPTP）小鼠多巴胺能神经退行性变模型中使用MRE来研究大脑对成年海马神经发生的机械反应，这是健康和损伤大脑中神经元可塑性的强大相关性。我们观察到，在MPTP治疗6天后，海马区域的弹性瞬间急剧上升超过50%，这与齿状回神经元密度增加有关，而这在健康对照中没有发现。我们的研究结果首次表明，神经退行性变后产生的新神经元对大脑的机械支架有很大的贡献。因此，诊断性神经影像学可以针对表现出症状性升高的弹性值的大脑区域，以检测神经变性后的神经元可塑性。
The mechanical network of the brain is a major contributor to neural health and has been recognized by in vivo magnetic resonance elastography (MRE) to be highly responsive to diseases. However, until now only brain softening was observed and no mechanism was known that reverses the common decrement of neural elasticity during aging or disease. We used MRE in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) mouse model for dopaminergic neurodegeneration as observed in Parkinson’s disease (PD) to study the mechanical response of the brain on adult hippocampal neurogenesis as a robust correlate of neuronal plasticity in healthy and injured brain. We observed a steep transient rise in elasticity within the hippocampal region of up to over 50% six days after MPTP treatment correlating with increased neuronal density in the dentate gyrus, which could not be detected in healthy controls. Our results provide the first indication that new neurons reactively generated following neurodegeneration substantially contribute to the mechanical scaffold of the brain. Diagnostic neuroimaging may thus target on regions of the brain displaying symptomatically elevated elasticity values for the detection of neuronal plasticity following neurodegeneration.
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通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2.5
作者：
Kronenberg, G;Reuter, K;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
3.2
作者：
Barnhill, Eric;Kennedy, Paul;Roberts, Neil
通讯作者：
Roberts, Neil
朝向大脑解剖结构的弹性图。
影响因子：
3.7
作者：
Guo J;Hirsch S;Fehlner A;Papazoglou S;Scheel M;Braun J;Sack I
通讯作者：
Sack I
影响因子：
2.4
作者：
Klaissle P;Lesemann A;Huehnchen P;Hermann A;Storch A;Steiner B
通讯作者：
Steiner B