Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner.
Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner.
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DOI：
10.1186/1471-2202-13-132
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发表时间：
2012-10-31
期刊：
影响因子：
2.4
通讯作者：
Steiner B
中科院分区：
文献类型：
--
作者：
Klaissle P;Lesemann A;Huehnchen P;Hermann A;Storch A;Steiner B
帕金森病的特征在于黑质（SN）内的神经元的持续损失，导致多巴胺的耗尽。在作为非神经源性区域的成人SN内，连续产生主要具有少突胶质细胞前体特征的表达神经胶质抗原-2（NG 2）的细胞。这些细胞的增殖在帕金森病（PD）的动物模型中改变。运动和环境富集重新增加PD模型中NG 2+细胞的增殖，然而，多巴胺对这种增加的可能机制作用尚未完全了解。NG 2+细胞可以分化成少突胶质细胞，但也可以分化成小胶质细胞和神经元，如在体外观察到的，这表明SN的内源性再生能力的可能暗示。我们研究了多巴胺在NG 2生成和分化的成年SN刺激的身体活动和环境丰富的作用。我们使用1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）模型进行多巴胺耗竭，并根据自愿体力活动，丰富的环境和左旋多巴治疗，在不同的成熟阶段和时间点分析SN中的新生细胞。我们描述了一种活性诱导的增加新的NG 2阳性细胞，也成熟的少突胶质细胞在SN的健康小鼠。跑步和丰富的环境拒绝刺激MPTP小鼠的NG 2代和少突细胞生成，这种作用可以通过药理学左旋多巴诱导的拯救来逆转。我们建议多巴胺是一个关键的调节活性诱导产生的NG 2细胞和少突胶质细胞在SN作为一个潜在的相关机制，内源性黑质细胞可塑性。
Parkinson’s disease is characterized by a continuous loss of neurons within the substantia nigra (SN) leading to a depletion of dopamine. Within the adult SN as a non-neurogenic region, cells with mainly oligodendrocytic precursor characteristics, expressing the neuro-glial antigen-2 (NG2) are continuously generated. Proliferation of these cells is altered in animal models of Parkinson’s disease (PD). Exercise and environmental enrichment re-increase proliferation of NG2+ cells in PD models, however, a possible mechanistic role of dopamine for this increase is not completely understood. NG2+ cells can differentiate into oligodendrocytes but also into microglia and neurons as observed in vitro suggesting a possible hint for endogenous regenerative capacity of the SN. We investigated the role of dopamine in NG2-generation and differentiation in the adult SN stimulated by physical activity and environmental enrichment. We used the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model for dopamine depletion and analysed newborn cells in the SN at different maturation stages and time points depending on voluntary physical activity, enriched environment and levodopa-treatment. We describe an activity- induced increase of new NG2-positive cells and also mature oligodendrocytes in the SN of healthy mice. Running and enriched environment refused to stimulate NG2-generation and oligodendrogenesis in MPTP-mice, an effect which could be reversed by pharmacological levodopa-induced rescue. We suggest dopamine being a key regulator for activity-induced generation of NG2-cells and oliogodendrocytes in the SN as a potentially relevant mechanism in endogenous nigral cellular plasticity.
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影响因子：
7.8
作者：
Aguirre, Adan A;Chittajallu, Ramesh;Belachew, Shibeshih;Gallo, Vittorio
通讯作者：
Gallo, Vittorio
影响因子：
4.7
作者：
Anastasía A;Torre L;de Erausquin GA;Mascó DH
通讯作者：
Mascó DH
影响因子：
2.5
作者：
Kronenberg, G;Reuter, K;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
--
作者：
Barcia, Carlos;Ros, Carmen M.;Herrero, Maria-Trinidad
通讯作者：
Herrero, Maria-Trinidad
影响因子：
5.3
作者：
Bull, ND;Bartlett, PF
通讯作者：
Bartlett, PF