Bacillus anthracis physiology and genetics.
Bacillus anthracis physiology and genetics.
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DOI：
10.1016/j.mam.2009.07.004
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发表时间：
2009-12
影响因子：
10.6
通讯作者：
Koehler, Theresa M.
中科院分区：
文献类型：
--
作者：
Koehler, Theresa M.
炭疽芽孢杆菌是蜡状芽孢杆菌组物种（也称为“组1芽孢杆菌”）的成员，该组物种是革兰氏阳性孢子形成土壤细菌的集合，其是非苛养兼性厌氧菌，具有非常相似的生长特征和天然遗传交换系统。尽管它们的生理学和遗传学接近，但蜡样芽孢杆菌组物种表现出某些物种特异性表型，其中一些与致病性有关。B。炭疽是炭疽病的病原体。B的营养细胞。炭疽杆菌在感染哺乳动物宿主期间和在被认为模拟宿主环境的条件下培养时产生炭疽毒素蛋白和聚-D-谷氨酸胶囊。与毒素和荚膜合成相关的基因位于B上。炭疽菌质粒pXO 1和pXO 2。虽然质粒含量被认为是该物种的一个定义特征，但已在与B的其他成员更相似的菌株中鉴定出pXO 1和pXO 2样质粒。cereus群。B的发展性。炭疽菌及其致病性（哺乳动物宿主）和环境（土壤）生活方式使其成为研究生态位特异性细菌基因表达和生理学的有趣模型。
Bacillus anthracis is a member of the Bacillus cereus group species (also known as the “group 1 bacilli”), a collection of Gram-positive spore-forming soil bacteria that are non-fastidious facultative anaerobes with very similar growth characteristics and natural genetic exchange systems. Despite their close physiology and genetics, the Bacillus cereus group species exhibit certain species-specific phenotypes, some of which are related to pathogenicity. B. anthracis is the etiologic agent of anthrax. Vegetative cells of B. anthracis produce anthrax toxin proteins and a poly-D-glutamic acid capsule during infection of mammalian hosts and when cultured in conditions considered to mimic the host environment. The genes associated with toxin and capsule synthesis are located on the B. anthracis plasmids, pXO1 and pXO2, respectively. Although plasmid content is considered a defining feature of the species, pXO1- and pXO2-like plasmids have been identified in strains that more closely resemble other members of the B. cereus group. The developmental nature of B. anthracis and its pathogenic (mammalian host) and environmental (soil) lifestyles of make it an interesting model for study of niche-specific bacterial gene expression and physiology.
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影响因子：
3.1
作者：
BARTKUS, JM;LEPPLA, SH
通讯作者：
LEPPLA, SH
影响因子：
2.8
作者：
ACKERMANN, HW;ROY, R;SMIRNOFF, WA
通讯作者：
SMIRNOFF, WA
影响因子：
4
作者：
Charlton, S.;Herbert, M.;Hallis., B.
通讯作者：
Hallis., B.
影响因子：
3.6
作者：
CATALDI, A;LABRUYERE, E;MOCK, M
通讯作者：
MOCK, M
影响因子：
3.2
作者：
Chen, YH;Succi, J;Koehler, TM
通讯作者：
Koehler, TM