Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate.

Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate.
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DOI:
10.1038/nnano.2009.5
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发表时间:
2009-04
影响因子:
38.3
通讯作者:
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中科院分区:
材料科学1区
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The aim of nanotechnology is to put specific atomic and molecular species where we want them, when we want them there. Achieving such dynamic and functional control could lead to programmable chemical synthesis and nanoscale systems that are responsive to their environments. Structural DNA nanotechnology offers a powerful route to this goal by combining stable branched DNA motifs with cohesive ends to produce programmed nanomechanical devices and fixed,,or modified,patterned lattices. Here, we demonstrate a dynamic form of patterning in which a pattern component is captured between two independently programmed DNA devices. A simple and robust error-correction protocol has been developed that yields programmed targets in all cases. This capture system can lead to dynamic control either on patterns or on programmed elements; this capability enables computation or a change of structural state as a function of information in the surroundings of the system.
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