A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System.

A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System.
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DOI:
10.3390/s91109255
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发表时间:
2009
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Henderson RK
Henderson RK
中科院分区:
其他
文献类型:
--
作者:
Rae BR;Muir KR;Gong Z;McKendry J;Girkin JM;Gu E;Renshaw D;Dawson MD;Henderson RK

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我们描述了一种用于时间分辨荧光寿命分析的基于CMOS微系统。它包括一个16×4的单光子雪崩二极管阵列(SPAD),该阵列采用0.35μm高压cmos工艺制造,具有像素内时间门控光子计数电路;第二个器件包括一个8×8的AlInGaN蓝色微像素化发光二极管阵列,该阵列凸点键合到用标准低电压0.35μm cmos工艺实现的等效LED驱动器阵列,能够产生宽度为777 ps(半高宽)的激励脉冲。该系统用基于PC的微型系统取代了基于激光、光电倍增管、大块光学和分立电子学的仪器。给出了胶体量子点和罗丹明样品的演示寿命测量结果。
We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.
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