Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride.
Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride.
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青春期后期的酒精暴露会增加成年 Wistar 大鼠的饮酒量，但非那雄胺不会减少这种影响。
DOI：
10.1093/alcalc/ags105
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Covault,Jonathan
中科院分区：
文献类型：
--
作者：
Milivojevic,Verica;Covault,Jonathan
目的：我们测试了在青春期后期（神经活性类固醇前体迅速增加的年龄）接触酒精是否会增加成年大鼠的自愿饮酒量，以及这种效应是否会受到非那雄胺（一种神经活性类固醇合成抑制剂）的调节。方法：在实验1中，我们在青春期后期[出生后天数（PND）51-58]期间将雄性Wistar大鼠在黑暗周期中暴露于8％酒精中1周，然后测量自愿酒精摄入量成年后 1 个月消费（PNDs 91-104）。在实验 2 中，非那雄胺在青春期后期被迫饮酒期间服用，而在实验 3 中，则在成年期自愿饮酒期间服用。在每次非那雄胺治疗结束时收集血浆，以确认血浆神经活性类固醇水平的降低。结果：我们发现，在青春期后期连续 7 天每天 12 小时接触酒精会显着增加一个月后成年期间的自愿饮酒量（4 倍）。青春期后期服用非那雄胺增加了青春期后期的群体酒精摄入量，但并没有阻止青少年酒精暴露对成年期酒精偏好增加的影响。成年期非那雄胺治疗对酒精偏好没有影响。结论：青春期后期连续7天每天12小时接触酒精足以诱发成年期酒精偏好的慢性增加，表明这个年龄可能对酒精的影响敏感。
Aims:We tested whether an exposure to alcohol in late adolescence, an age of rapid increase in neuroactive steroid precursors, would increase voluntary alcohol consumption in adult rats and whether this effect would be modulated by finasteride, an inhibitor of neuroactive steroid synthesis.Methods:In Experiment 1, we exposed male Wistar rats to 8% alcohol during the dark cycle for 1 week during late adolescence [postnatal days (PNDs) 51–58], and then measured voluntary alcohol consumption 1 month later in adulthood (PNDs 91–104). In Experiment 2, finasteride was administered during the forced alcohol exposure in late adolescence and, in Experiment 3, during voluntary alcohol consumption in adulthood. Plasma was collected at the end of each finasteride treatment to confirm the reduction of plasma neuroactive steroid levels.Results:We found that a daily 12-h exposure to alcohol for 7 days in late adolescence significantly increased voluntary alcohol consumption (4-fold) a month later during adulthood. Finasteride administration in late adolescence increased group alcohol intake in late adolescence but did not block the effect of adolescent alcohol exposure on increasing alcohol preference in adulthood. There was no effect of finasteride treatment in adulthood on alcohol preference.Conclusions:A daily 12-h exposure to alcohol for 7 days in late adolescence was sufficient to induce chronically increased alcohol preference in adulthood, indicating that this age may be sensitive to the effects of alcohol.
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