Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.
Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.
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DOI：
10.1016/j.neuroscience.2012.10.028
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发表时间：
2013-06-03
期刊：
影响因子：
3.3
通讯作者：
Sengelaub, D. R.
中科院分区：
文献类型：
--
作者：
Verhovshek, T.;Rudolph, L. M.;Sengelaub, D. R.
神经营养因子和类固醇激素相互作用，以调节各种神经元的过程，如轴突生长，分化和神经保护。类固醇激素和神经营养因子受体mRNA和蛋白的共表达以及它们的相互调节为这种相互作用的发生提供了必要的底物。这篇综述将集中在脊髓中的雄激素-BDNF的相互作用，描述去势、雄激素操纵和损伤后神经肌肉系统中BDNF的雄激素调节。雄激素在发育过程中与BDNF相互作用，以调节正常发生的运动神经元死亡，在成年期，雄激素-BDNF相互作用参与维持神经肌肉系统的几个特征。雄激素调节脊髓运动神经元BDNF和trkB的表达。雄激素还调节靶肌肉组织中的BDNF水平，并且肌肉中的雄激素作用调节运动神经元中的BDNF水平。这些相互作用对运动神经元形态的维持具有重要意义。最后，损伤后雄激素与BDNF相互作用，影响索马大小、树突形态和轴突再生。总之，这些研究结果提供了进一步了解神经肌肉系统的发展和维护，并对雄激素和营养因子在运动神经元疾病治疗和损伤恢复中的神经治疗/神经保护作用产生影响。
Neurotrophic factors and steroid hormones interact to regulate a variety of neuronal processes such as neurite outgrowth, differentiation, and neuroprotection. The coexpression of steroid hormone and neurotrophin receptor mRNAs and proteins, as well as their reciprocal regulation provides the necessary substrates for such interactions to occur. This review will focus on androgen-BDNF interactions in the spinal cord, describing androgen regulation of BDNF in neuromuscular systems following castration, androgen manipulation, and injury. Androgens interact with BDNF during development to regulate normally-occurring motoneuron death, and in adulthood, androgen-BDNF interactions are involved in the maintenance of several features of neuromuscular systems. Androgens regulate BDNF and trkB expression in spinal motoneurons. Androgens also regulate BDNF levels in the target musculature, and androgenic action at the muscle regulates BDNF levels in motoneurons. These interactions have important implications for the maintenance of motoneuron morphology. Finally, androgens interact with BDNF after injury, influencing soma size, dendritic morphology, and axon regeneration. Together, these findings provide further insight into the development and maintenance of neuromuscular systems and have implications for the neurotherapeutic/neuroprotective roles of androgens and trophic factors in the treatment of motoneuron disease and recovery from injury.
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影响因子：
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