Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study.
Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study.
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DOI：
10.1088/0031-9155/59/5/1121
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发表时间：
2014-03-07
影响因子：
3.5
通讯作者：
Konofagou EE
中科院分区：
文献类型：
--
作者：
Hou GY;Marquet F;Wang S;Konofagou EE
聚焦超声谐波运动成像技术（Harmonic Motion Imaging for Focused Ultrasound，HMIFU）是近年来发展起来的一种高强度聚焦超声（High-intensity focused ultrasound，HIFU）治疗监测方法。在这里，多参数研究进行调查弹性和声学独立的粘弹性组织的变化，使用谐波运动成像（HMI）的位移，轴向压缩应变和相对相移的变化，在高能量HIFU治疗与组织沸腾。在离体犬肝脏标本（n=28）中形成了43处（n=43）热损伤。在损伤形成之前和之后还获得了二维（2D）横向HMI位移图。在10-s、20-s和30-s HIFU持续时间内，以8、10和11 W的三种不同声功率重复相同的方法，选择并验证这些声功率作为能够使用热电偶和被动空化检测（PCD）测量诱导沸腾的治疗参数。尽管在许多情况下获得了位移、压缩应变和焦点相移（Δφ）的相对变化的稳定降低，表明相对刚度总体增加，但研究结果还表明，在煮沸期间，检测到反向损伤-背景位移对比，表明组织吸收、几何变化和/或机械凝胶化或粉碎的潜在变化。治疗后，热损伤的相应2D HMI位移图像也映射了损伤与背景位移对比度的一致差异。尽管沸腾时声学特性发生了不可预测的变化，但相移的相对变化显示出一致的下降，表明其在整个HIFU治疗过程中独立于声学特性变化监测生物力学特性的稳健性。此外，2D HMI位移图像证实并表明热损伤尺寸随治疗持续时间增加，这一点经病理学验证。总之，多参数HIFU能够监测和映射组织的粘弹性响应的变化，在HIFU沸腾，其中一些是独立的声学参数的变化。
Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in vitro and in vivo. Here, a multi-parametric study is performed to investigate both elastic and acoustics-independent viscoelastic tissue changes using the Harmonic Motion Imaging (HMI) displacement, axial compressive strain and change in relative phase-shift during high energy HIFU treatment with tissue boiling. Forty three (n=43) thermal lesions were formed in ex vivo canine liver specimens (n=28). Two dimensional (2D) transverse HMI displacement maps were also obtained before and after lesion formation. The same method was repeated in 10-s, 20-s and 30-s HIFU durations at three different acoustic powers of 8, 10, and 11W, which were selected and verified as treatment parameters capable of inducing boiling using both thermocouple and Passive Cavitation Detection (PCD) measurements. Although a steady decrease in the displacement, compressive strain, and relative change in the focal phase shift (Δφ) were obtained in numerous cases, indicating an overall increase in relative stiffness, the study outcomes also showed that during boiling, a reverse lesion-to-background displacement contrast was detected, indicating potential change in tissue absorption, geometrical change and/or, mechanical gelatification or pulverization. Following treatment, corresponding 2D HMI displacement images of the thermal lesions also mapped consistent discrepancy in the lesion-to-background displacement contrast. Despite unpredictable changes in acoustic properties with boiling, the relative change in phase shift showed a consistent decrease, indicating its robustness to monitor biomechanical properties independent of the acoustic property change throughout the HIFU treatment. In addition, the 2D HMI displacement images confirmed and indicated the increase in the thermal lesion size with treatment duration, which was validated against pathology. In conclusion, multi-parametric HMIFU was shown capable of monitoring and mapping tissue viscoelastic response changes during and after HIFU boiling, some of which were independent of the acoustic parameter changes.
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影响因子：
2.9
作者：
Curiel, Laura;Chopra, Rajiv;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
影响因子：
2.3
作者：
Bing KF;Rouze NC;Palmeri ML;Rotemberg VM;Nightingale KR
通讯作者：
Nightingale KR
影响因子：
3.8
作者：
Gianfelice, D;Khiat, A;Boulanger, Y
通讯作者：
Boulanger, Y
DOI：
10.1073/pnas.96.12.6603
发表时间：
1999-06-08
影响因子：
11.1
作者：
Fatemi, M;Greenleaf, JF
通讯作者：
Greenleaf, JF
影响因子：
2.9
作者：
Curiel, L;Souchon, R;Chapelon, JY
通讯作者：
Chapelon, JY