In vivo monitoring of focused ultrasound surgery using local harmonic motion.
In vivo monitoring of focused ultrasound surgery using local harmonic motion.
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DOI：
10.1016/j.ultrasmedbio.2008.07.001
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发表时间：
2009-01
影响因子：
2.9
通讯作者：
Hynynen, Kullervo
中科院分区：
文献类型：
--
作者：
Curiel, Laura;Chopra, Rajiv;Hynynen, Kullervo
本研究建立了一种技术的可行性，用于监测FUS病变形成在体内使用本地化谐波运动（LHM）测量。振荡运动（频率在50和300 Hz之间）是通过用聚焦超声（FUS）换能器诱导周期性辐射力在组织内产生的。利用共焦诊断超声换能器在运动过程中不同时刻采集的RF超声信号的互相关来估计谐波运动。在兔肌肉（14个位置）中，在MR成像仪中同时进行超声谐波运动跟踪和MR测温，对该技术进行了体内评价。在损伤形成之前和之后，对于所有测试的运动频率，所测量的诱导谐波运动的最大振幅显著不同，并且根据频率和位置降低17%至81%。在FUS暴露期间，观察到最大振幅值下降，并且阈值可能与热损伤的形成相关。一系列的控制声处理，通过停止曝光时，在LHM振幅达到阈值和热损伤的存在下，通过MR成像证实。LHM测量也被用来执行跨暴露区域的组织的空间扫描，并且热损伤可以被检测为在超声处理区域处的最大运动幅度值的减小。
The present study established the feasibility of a technique for monitoring FUS lesion formation in vivo using localized harmonic motion (LHM) measurements. Oscillatory motion (frequencies between 50 and 300 Hz) was generated within tissues by induction of a periodic radiation force with a focused ultrasound (FUS) transducer. The harmonic motion was estimated using cross-correlation of RF ultrasonic signals acquired at different instances during the motion by using a confocal diagnostic ultrasound transducer. The technique was evaluated in vivo in rabbit muscle (14 locations) in an MR imager for simultaneous ultrasound harmonic motion tracking and MR thermometry. The measured maximum amplitude of the induced harmonic motion before and after the lesion formation was significantly different for all the tested motion frequencies and decreased between 17 and 81% depending on the frequency and location. During the FUS exposure a drop in the maximum amplitude value was observed and a threshold value could be associated to the formation of a thermal lesion. A series of controlled sonications was performed by stopping the exposure when the threshold value in LHM amplitude was reached and the presence of a thermal lesion was confirmed by MR imaging. LHM measurements were also used to perform a spatial scan of the tissues across the exposure region and the thermal lesions could be detected as a reduction in the maximum motion amplitude value at the sonication region.
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影响因子：
56.9
作者：
Fatemi, M;Greenleaf, JF
通讯作者：
Greenleaf, JF
影响因子：
4.2
作者：
Konofagou, E;Thierman, J;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
3.3
作者：
Le, Y;Glaser, K;Felmlee, JP
通讯作者：
Felmlee, JP
影响因子：
2.9
作者：
BILLARD, BE;HYNYNEN, K;ROEMER, RB
通讯作者：
ROEMER, RB
影响因子：
3.8
作者：
Chopra, Rajiv;Baker, Nicole;Bronskill, Michael J.
通讯作者：
Bronskill, Michael J.