Prediction of outcome following paraquat poisoning by arterial lactate concentration-time data.
Prediction of outcome following paraquat poisoning by arterial lactate concentration-time data.
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通过动脉乳酸浓度-时间数据预测百草枯中毒后的结果。
DOI：
10.3892/etm.2014.1773
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发表时间：
2014-08
影响因子：
2.7
通讯作者：
Wei LQ
中科院分区：
文献类型：
--
作者：
Sun L;Li GQ;Yan PB;Liu Y;Li GF;Wei LQ
本研究回顾性分析了170例诊断为百草枯（PQ）中毒的患者，旨在阐明动脉乳酸时间（动脉乳酸浓度×摄入和动脉乳酸测量之间的时间）是否是急性PQ中毒患者死亡率的良好预测因子。结果表明，动脉乳酸盐-时间与PQ浓度-时间呈正相关（ρ=0.485）。此外，动脉乳酸盐-时间数据显示出与血浆PQ浓度-时间数据相似的区分能力（z=0.712; P=0.864）。对于受试者工作特征曲线分析，乳酸-时间数据的面积为0.782，临界值为11.95 mmol/l. h（敏感性，64.52%;特异性，84.42%）。为了计算任何指定时间和初始动脉乳酸盐浓度的预测生存概率，根据logistic回归系数推导出以下公式：Logit（p）= 3.066 − 0.139 ×（PQ摄入后的时滞）− 0.177 ×（初始动脉乳酸盐浓度）;其中生存概率= 1/1 + e−logit（p）。因此，动脉乳酸时间数据显示出良好的预测能力，评估急性PQ中毒患者的预后。
The present study retrospectively analyzed 170 patients diagnosed with paraquat (PQ) poisoning with the aim of clarifying whether the arterial lactate-time (arterial lactate concentration × time between ingestion and arterial lactate measurement) was a good predictor of mortality in patients with acute PQ poisoning. The results indicated that there was a positive correlation between the arterial lactate-time and PQ concentration-time (ρ=0.485). In addition, the arterial lactate-time data exhibited a similar discriminative power to the plasma PQ concentration-time data (z=0.712; P=0.864). For the receiver operating characteristic curve analysis, the lactate-time data had an area of 0.782 with a cut-off value of 11.95 mmol/l.h (sensitivity, 64.52%; specificity, 84.42%). To calculate the predicted probability of survival for any specified time and initial arterial lactate concentration, the following formula was derived based on the logistic regression coefficients: Logit(p) = 3.066 − 0.139 × (time lag following PQ ingestion) − 0.177 × (initial arterial lactate concentration); where the probability of survivors = 1/1 + e−logit(p). Therefore, the arterial lactate-time data exhibited a good predictive power for evaluating the prognosis of patients with acute PQ poisoning.
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影响因子：
3.3
作者：
Gil, Hyo-Wook;Kang, Mun-Soo;Hong, Sae-Yong
通讯作者：
Hong, Sae-Yong
DOI：
10.1016/j.jchromb.2007.11.002
发表时间：
2008-02-01
影响因子：
3
作者：
Posecion, Norberto C.;Ostrea, Enrique M.;Bielawski, Dawn M.
通讯作者：
Bielawski, Dawn M.
影响因子：
3.3
作者：
Lee, Younghwan;Lee, Jun Ho;Hwang, Seong Youn
通讯作者：
Hwang, Seong Youn
影响因子：
1.9
作者：
DELONG, ER;DELONG, DM;CLARKEPEARSON, DI
通讯作者：
CLARKEPEARSON, DI
DOI：
10.1093/qjmed/hcp006
发表时间：
2009-04
期刊：
QJM : monthly journal of the Association of Physicians
影响因子：
--
作者：
Senarathna L;Eddleston M;Wilks MF;Woollen BH;Tomenson JA;Roberts DM;Buckley NA
通讯作者：
Buckley NA