Redox changes in obesity, metabolic syndrome, and diabetes.
Redox changes in obesity, metabolic syndrome, and diabetes.
复制标题
氧化还原的肥胖，代谢综合征和糖尿病的变化。
DOI：
10.1016/j.redox.2021.101887
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发表时间：
2021-06
期刊：
影响因子：
11.4
通讯作者：
Jankovic A
中科院分区：
文献类型：
--
作者：
Korac B;Kalezic A;Pekovic-Vaughan V;Korac A;Jankovic A
“生命是循环物质和流动能量的瞬间相遇”（塞尔维亚生理学家Jean Giaja），不仅是生命的最优雅定义之一，而且是氧化还原生物学和新陈代谢的关系。它们的进化联系创造了不可分割的动态健康平衡，当这种平衡被破坏时，就会导致疾病。这种相互联系在今天甚至更加相关，在一个代谢性疾病如肥胖、代谢综合征和糖尿病等流行病比例增加的时代。尽管在理解氧化还原和代谢调节的分子机制方面取得了很大进展，但我们在预防、诊断和治疗代谢性疾病方面仍面临重大挑战。这些综合征的病因学关联和时间重叠对鉴别用于诊断、治疗和结果预测的适当临床生物标志物提出了重大挑战。这些多因素、多器官代谢综合征具有复杂的发病机制，并伴有靶组织和循环中氧化还原平衡紊乱。自由基和活性物质被认为是疾病状态的因果因素和后果。因此，确定自由基和活性物质的亚型和水平，氧化损伤的生物分子（脂质，蛋白质和核酸）和抗氧化防御成分以及氧化还原敏感的转录因子和氧化还原依赖性代谢途径的通量将有助于定义现有的和建立新的氧化还原生物标志物分层代谢疾病。本综述旨在讨论肥胖、代谢综合征和糖尿病中不同的氧化还原/代谢方面，以帮助建立一个平台，用于精准医学中新兴和未来的氧化还原代谢生物标志物研究。未来的研究需要对健康受试者和患者中氧化还原生物标志物的状态进行详细调查，包括使用新兴的“组学”分析技术（例如，氧化还原蛋白质组、脂质组、代谢物组和转录物组），同时考虑到生活方式（饮食、体力活动、睡眠、工作模式）以及循环因子和代谢物的昼夜~ 24小时波动的影响。肥胖、代谢综合征和糖尿病都是氧化还原疾病。氧化还原-代谢界面是氧化还原生物标志物研究的肥沃土壤。氧化还原生物标志物的验证可能有助于代谢性疾病的诊断、诊断和治疗。昼夜节律影响代谢性疾病的氧化还原代谢完整性。氧化还原生物标志物将癌症与肥胖、代谢综合征和糖尿病联系起来。
"Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the relationship of redox biology and metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease. This interconnection is even more pertinent today, in an era of increasing metabolic diseases of epidemic proportions such as obesity, metabolic syndrome, and diabetes. Despite great advances in understanding the molecular mechanisms of redox and metabolic regulation, we face significant challenges in preventing, diagnosing, and treating metabolic diseases. The etiological association and temporal overlap of these syndromes present significant challenges for the discrimination of appropriate clinical biomarkers for diagnosis, treatment, and outcome prediction. These multifactorial, multiorgan metabolic syndromes with complex etiopathogenic mechanisms are accompanied by disturbed redox equilibrium in target tissues and circulation. Free radicals and reactive species are considered both a causal factor and a consequence of disease status. Thus, determining the subtypes and levels of free radicals and reactive species, oxidatively damaged biomolecules (lipids, proteins, and nucleic acids) and antioxidant defense components as well as redox-sensitive transcription factors and fluxes of redox-dependent metabolic pathways will help define existing and establish novel redox biomarkers for stratifying metabolic diseases. This review aims to discuss diverse redox/metabolic aspects in obesity, metabolic syndrome, and diabetes, with the imperative to help establish a platform for emerging and future redox-metabolic biomarkers research in precision medicine. Future research warrants detailed investigations into the status of redox biomarkers in healthy subjects and patients, including the use of emerging 'omic' profiling technologies (e.g., redox proteomes, lipidomes, metabolomes, and transcriptomes), taking into account the influence of lifestyle (diet, physical activity, sleep, work patterns) as well as circadian ~24h fluctuations in circulatory factors and metabolites. Obesity, metabolic syndrome, and diabetes are redox diseases. The redox-metabolic interface is a fertile ground for redox biomarkers research. Validation of redox biomarkers could be instrumental in metabolic disease diagnostics, prognostics, and therapy. Circadian rhythms affect the redox-metabolic integrity of metabolic diseases. Redox biomarkers link cancer with obesity, metabolic syndrome, and diabetes.
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DOI：
10.1124/jpet.109.162271
发表时间：
2010-04-01
影响因子：
3.5
作者：
Aleksunes, Lauren M.;Reisman, Scott A.;Klaassen, Curtis D.
通讯作者：
Klaassen, Curtis D.
影响因子：
17.1
作者：
Axelsson, Annika S.;Tubbs, Emily;Rosengren, Anders H.
通讯作者：
Rosengren, Anders H.
影响因子：
6.6
作者：
Barocas, Daniel A.;Motley, Saundra;Fowke, Jay H.
通讯作者：
Fowke, Jay H.
影响因子：
7.1
作者：
Blanco, Roberto A.;Ziegler, Thomas R.;Jones, Dean P.
通讯作者：
Jones, Dean P.
影响因子：
7.2
作者：
Arif, M.;Islam, M. R.;Kabir, Y.
通讯作者：
Kabir, Y.