Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
复制标题
DOI：
10.1002/dvdy.22369
复制
发表时间：
2010-09
影响因子：
2.5
通讯作者：
Levenson, Robert
中科院分区：
文献类型：
--
作者：
Jin, Jay;Morse, Megan;Frey, Colleen;Petko, Jessica;Levenson, Robert
GPR177 is an evolutionarily conserved transmembrane protein necessary for Wnt protein secretion. Little is currently known, however, regarding expression of GPR177, especially in vertebrate species. We have developed an antiserum against GPR177, and used it to examine expression of GPR177 in human tissue culture cells, adult mouse and rat tissues, as well as developing zebrafish embryos. In rodents, GPR177 is expressed in virtually all tissue types and brain regions examined. In zebrafish, GPR177 polypeptides are expressed throughout embryogenesis, and are detectable as early as one hour post-fertilization. In situ hybridization analysis reveals that gpr177 mRNA expression is prominent in embryonic zebrafish brain and ear. Structural studies suggest that GPR177 is modified by N-linked sugars, and that the protein contains an even number of transmembrane segments. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
登录
查看更多内容
影响因子：
2.4
作者：
Jin J;Kittanakom S;Wong V;Reyes BA;Van Bockstaele EJ;Stagljar I;Berrettini W;Levenson R
通讯作者：
Levenson R
影响因子：
2.9
作者：
CANFIELD, VA;LEVENSON, R
通讯作者：
LEVENSON, R
影响因子：
64.8
作者：
Reya, T;Duncan, AW;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
64.8
作者：
Reya, T;Clevers, H
通讯作者：
Clevers, H
影响因子：
64.5
作者：
Korkut C;Ataman B;Ramachandran P;Ashley J;Barria R;Gherbesi N;Budnik V
通讯作者：
Budnik V