Role of MicroRNA in Endothelial Dysfunction and Hypertension.
Role of MicroRNA in Endothelial Dysfunction and Hypertension.
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DOI：
10.1007/s11906-016-0696-8
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发表时间：
2016-12
影响因子：
5.6
通讯作者：
Georgescu A
中科院分区：
文献类型：
--
作者：
Nemecz M;Alexandru N;Tanko G;Georgescu A
高血压是内皮功能障碍的原因或后果，也是心血管疾病（CVD）的主要危险因素。体外和体内研究证实，microRNAs（miRNAs）在与CVD相关的各种病理条件下对内皮细胞基因表达和功能具有决定性作用。本文综述了miRNA在控制内皮功能障碍和高血压之间的关键联系中的作用。本文综述了高血压及其相关内皮功能障碍的机制，以及miRNA在内皮细胞中的作用，着重阐述了高血压内皮功能障碍对肾素-血管紧张素-醛固酮系统、一氧化氮、氧化应激的调节，以及对血管炎症和血管生成的调控。特别是，在内皮特异性microRNA及其靶点的鉴定方面的最新见解增加了对高血压中miRNA意义的理解。对miRNA在内皮功能障碍和高血压中的作用以及miRNA作用的分子机制的全面了解可能为控制高血压相关的内皮功能障碍和其他心血管并发症提供新的诊断生物标志物和治疗靶点。
Hypertension is either a cause or a consequence of the endothelial dysfunction and a major risk factor for cardiovascular disease (CVD). In vitro and in vivo studies established that microRNAs (miRNAs) are decisive for endothelial cell gene expression and function in various pathological conditions associated with CVD. This review provides an overview of the miRNA role in controlling the key connections between endothelial dysfunction and hypertension. Herein we summarize the present understanding of mechanisms underlying hypertension and its associated endothelial dysfunction as well as the miRNA role in endothelial cells with accent on the modulation of renin-angiotensin-aldosterone-system, nitric oxide, oxidative stress and on the control of vascular inflammation and angiogenesis in relation to endothelial dysfunction in hypertension. In particular, latest insights in the identification of endothelial-specific microRNAs and their targets are added to the understanding of miRNA significance in hypertension. This comprehensive knowledge of the role of miRNAs in endothelial dysfunction and hypertension and of molecular mechanisms proposed for miRNA actions may offer novel diagnostic biomarkers and therapeutic targets for controlling hypertension-associated endothelial dysfunction and other cardiovascular complications.
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