The rate of telomere loss is related to maximum lifespan in birds.
The rate of telomere loss is related to maximum lifespan in birds.
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端粒损失率与鸟类的最大寿命有关。
DOI：
10.1098/rstb.2016.0445
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发表时间：
2018-03-05
期刊：
影响因子：
--
通讯作者：
Haussmann MF
中科院分区：
文献类型：
--
作者：
Tricola GM;Simons MJP;Atema E;Boughton RK;Brown JL;Dearborn DC;Divoky G;Eimes JA;Huntington CE;Kitaysky AS;Juola FA;Lank DB;Litwa HP;Mulder EGA;Nisbet ICT;Okanoya K;Safran RJ;Schoech SJ;Schreiber EA;Thompson PM;Verhulst S;Wheelwright NT;Winkler DW;Young R;Vleck CM;Haussmann MF
端粒是DNA的高度保守区域，保护线性染色体的末端。端粒的丢失可以发出细胞状态不可逆变化的信号，包括细胞衰老。衰老细胞不再分裂，并可能损害附近的健康细胞，从而可能使它们处于癌症和衰老的十字路口。虽然端粒的流行病学，细胞和分子生物学研究得很好，但在生态学和进化的背景下探索端粒生物学的新领域才刚刚出现。由于迄今为止的工作主要集中在端粒缩短与个体死亡率的关系上，因此对端粒与物种衰老率的关系知之甚少。在这里，我们调查了端粒长度的横截面样本从19种鸟类，以确定端粒损失率与种间变异的最大寿命。我们发现，与寿命较短的物种相比，寿命较长的鸟类每年丢失的端粒重复序列较少。此外，系统发育分析表明，端粒丢失率是进化保守的鸟类家庭。这表明端粒缩短的生理原因，或维持端粒的能力，是可能负责或共同进化的特征，不同物种之间观察到的不同寿命。这篇文章是“理解端粒动力学的多样性”主题的一部分。
Telomeres are highly conserved regions of DNA that protect the ends of linear chromosomes. The loss of telomeres can signal an irreversible change to a cell's state, including cellular senescence. Senescent cells no longer divide and can damage nearby healthy cells, thus potentially placing them at the crossroads of cancer and ageing. While the epidemiology, cellular and molecular biology of telomeres are well studied, a newer field exploring telomere biology in the context of ecology and evolution is just emerging. With work to date focusing on how telomere shortening relates to individual mortality, less is known about how telomeres relate to ageing rates across species. Here, we investigated telomere length in cross-sectional samples from 19 bird species to determine how rates of telomere loss relate to interspecific variation in maximum lifespan. We found that bird species with longer lifespans lose fewer telomeric repeats each year compared with species with shorter lifespans. In addition, phylogenetic analysis revealed that the rate of telomere loss is evolutionarily conserved within bird families. This suggests that the physiological causes of telomere shortening, or the ability to maintain telomeres, are features that may be responsible for, or co-evolved with, different lifespans observed across species. This article is part of the theme issue ‘Understanding diversity in telomere dynamics'.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
5.4
作者：
Aviv, Abraham;Kark, Jeremy D.;Susser, Ezra
通讯作者：
Susser, Ezra
影响因子：
7.8
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
影响因子：
3.3
作者：
Boonekamp, Jelle J.;Bauch, Christina;Verhulst, Simon
通讯作者：
Verhulst, Simon