Osteolytic Indicators Found in Total Knee Arthroplasty Synovial Fluid Aspirates
Osteolytic Indicators Found in Total Knee Arthroplasty Synovial Fluid Aspirates
复制标题
全膝关节置换术滑液抽吸物中发现溶骨指标
DOI：
--
复制
发表时间：
2000
影响因子：
4.2
通讯作者：
T. S. Alexander
中科院分区：
文献类型：
--
作者：
M. Kovacik;I. Gradisar;J. J. Haprian;T. S. Alexander
检查了滑液抽吸物中的白细胞介素-1 β和抗酒石酸酸性磷酸酶浓度，以确定它们是否可用作全膝关节置换术患者滑膜炎症增加和溶骨性反应的指标。从7例严重骨关节炎膝关节患者（计划进行初次全膝关节置换术）和20例膝关节计划进行全膝关节置换术翻修的患者中获得滑膜抽吸物。11例翻修病例涉及钛合金假体，9例涉及钴Chrome合金假体。比较初次全膝关节置换术组和翻修术组的白细胞介素-1 β和抗酒石酸酸性磷酸酶浓度。接受翻修手术的膝关节的白细胞介素-1 β和抗酒石酸酸性磷酸酶浓度高于接受初次全膝关节置换术的膝关节。这些结果表明翻修手术的膝关节炎性反应和溶骨性反应更大。尽管本研究中的骨关节炎膝关节和需要翻修手术的膝关节被认为具有炎症状态，但只有在全膝关节置换术后，当存在颗粒磨损碎屑时，才会产生明显浓度的白细胞介素-1 β和抗酒石酸酸性磷酸酶。
Interleukin-1β and tartrate resistant acid phosphatase concentrations in synovial fluid aspirates were examined to determine if they could be used as indicators of increased synovial inflammation and an osteolytic reaction in patients having total knee arthroplasty. Synovial aspirates were obtained from seven patients with severely osteoarthritic knees that were scheduled for primary total knee arthroplasty and from 20 patients with knees scheduled for total knee arthroplasty revision. Eleven of the revision cases involved titanium alloy prostheses and nine involved cobalt chrome alloy prostheses. The interleukin-1β and tartrate resistant acid phosphatase concentrations were obtained and compared between the group having primary total knee arthroplasty and the group having revision total knee arthroplasty. The knees having revision surgery had higher concentrations of interleukin-1β and tartrate resistant acid phosphatase than did the knees having primary total knee arthroplasty. These results indicate a greater inflammatory and osteolytic response in knees having revision surgery. Although the osteoarthritic knees and the knees needing revision surgery in this study are considered to have an inflammatory state, it was only after total knee arthroplasty when particulate wear debris would be present that appreciable concentrations of interleukin-1β and tartrate resistant acid phosphatase were produced.
登录
查看更多内容
DOI：
10.2106/00004623-198365050-00001
发表时间：
1983-01-01
影响因子：
5.3
作者：
GOLDRING, SR;SCHILLER, AL;HARRIS, WH
通讯作者：
HARRIS, WH
石骨症动物模型：最新分子发展对治疗干预新策略的影响。
DOI：
10.1016/1357-4310(96)81801-6
发表时间：
1996
期刊：
Molecular medicine today.
影响因子：
--
作者：
Popoff,SN;Schneider,GB
通讯作者：
Schneider,GB
正常和骨石症大鼠的胫骨破骨细胞和异位骨和缝合植入物引起的细胞中的抗酒石酸酸性磷酸酶活性。
DOI：
--
发表时间：
1988
期刊：
Bone and mineral
影响因子：
--
作者：
Walters,LM;Schneider,GB
通讯作者：
Schneider,GB
DOI：
10.1002/jbm.820280111
发表时间：
1994-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
SHANBHAG, AS;JACOBS, JJ;GLANT, TT
通讯作者：
GLANT, TT