Increased anxiety in offspring reared by circadian Clock mutant mice.
Increased anxiety in offspring reared by circadian Clock mutant mice.
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DOI：
10.1371/journal.pone.0066021
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sanada K
中科院分区：
文献类型：
--
作者：
Koizumi H;Kurabayashi N;Watanabe Y;Sanada K
后代在生命早期从母亲那里得到的母亲照顾影响了后代成年后情感行为的发展。在这里，我们发现由生物钟受损的小鼠饲养的后代表现出与焦虑相关的行为增加。携带Clock突变的Clock突变小鼠，Clock是分子生物钟的关键组成部分，显示出改变的日常护理行为模式，在光照期间是片段化的，而不是野生型小鼠的长时间护理行为。Clock突变小鼠培育的成年野生型后代表现出增加的焦虑相关行为。这与出生后第14天大脑5-羟色胺水平的降低相结合，其在出生后早期的稳态对于成年后的正常情绪行为至关重要。总之，母亲生物钟的破坏对后代建立正常的焦虑水平有不利影响，这可能会增加他们患焦虑症的风险。
The maternal care that offspring receive from their mothers early in life influences the offspring’s development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutation in Clock, a key component of the molecular circadian clock, display altered daily patterns of nursing behavior that is fragmented during the light period, instead of long bouts of nursing behavior in wild-type mice. Adult wild-type offspring fostered by Clock mutant mice exhibit increased anxiety-related behavior. This is coupled with reduced levels of brain serotonin at postnatal day 14, whose homeostasis during the early postnatal period is critical for normal emotional behavior in adulthood. Together, disruption of the circadian clock in mothers has an adverse impact on establishing normal anxiety levels in offspring, which may increase their risk of developing anxiety disorders.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
4.8
作者：
Hoshino, K;Wakatsuki, Y;Shibata, S
通讯作者：
Shibata, S
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
影响因子：
56.9
作者：
Ansorge, MS;Zhou, MM;Gingrich, JA
通讯作者：
Gingrich, JA
DOI：
10.1073/pnas.54.1.90
发表时间：
1965-01-01
影响因子：
11.1
作者：
HARLOW, HF;DODSWORTH, RO;HARLOW, MK
通讯作者：
HARLOW, MK